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Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.红骨髓祖细胞：在造血干细胞出现之前，胚胎中的“确定性”造血。
Blood Cells Mol Dis. 2013 Dec;51(4):220-5. doi: 10.1016/j.bcmd.2013.09.006. Epub 2013 Oct 2.
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Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.在哺乳动物发育过程中，具有强大细胞毒性的自然杀伤细胞最初从红细胞-髓样祖细胞中出现。
Dev Cell. 2020 Apr 20;53(2):229-239.e7. doi: 10.1016/j.devcel.2020.02.016. Epub 2020 Mar 19.
3
Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection.鼠胚和卵黄囊中的淋巴祖细胞出现先于干细胞检测。
Stem Cells Dev. 2014 Jun 1;23(11):1168-77. doi: 10.1089/scd.2013.0536. Epub 2014 Feb 18.
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Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.小鼠卵黄囊和胚胎本身中红系和髓系祖细胞的发育。
Development. 1999 Nov;126(22):5073-84. doi: 10.1242/dev.126.22.5073.
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Signaling pathways implicated in hematopoietic progenitor cell proliferation and differentiation.与造血祖细胞增殖和分化相关的信号通路。
Exp Biol Med (Maywood). 2007 Jan;232(1):156-63.
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Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.Kit 配体在小鼠卵黄囊和体节-性腺-中肾造血中起着关键作用。
EMBO Rep. 2018 Oct;19(10). doi: 10.15252/embr.201745477. Epub 2018 Aug 30.
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Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.Hlf 标记造血干细胞的发育途径，但不标记红系-髓系祖细胞。
J Exp Med. 2019 Jul 1;216(7):1599-1614. doi: 10.1084/jem.20181399. Epub 2019 May 10.
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Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo.不依赖造血干细胞的造血作用：哺乳动物胚胎中红系、巨核系和髓系潜能的出现
FEBS Lett. 2016 Nov;590(22):3965-3974. doi: 10.1002/1873-3468.12459. Epub 2016 Oct 27.
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Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo.造血祖细胞的不同来源在造血干细胞之前出现，并在哺乳动物胚胎中提供功能性血细胞。
Cell Rep. 2015 Jun 30;11(12):1892-904. doi: 10.1016/j.celrep.2015.05.036. Epub 2015 Jun 18.
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CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis.CD41+ cmyb+前体细胞通过一条新的迁移途径定殖于斑马鱼前肾，从而启动成体造血过程。
Development. 2008 May;135(10):1853-62. doi: 10.1242/dev.015297. Epub 2008 Apr 16.
引用本文的文献
1
Metabolic reprogramming of fetal hematopoietic stem and progenitor cells by maternal obesity.母体肥胖对胎儿造血干细胞和祖细胞的代谢重编程作用。
Front Hematol. 2025;4. doi: 10.3389/frhem.2025.1575143. Epub 2025 Apr 14.
2
Embryonic mast cells arise from the Cpa3-expressing precursors but not granulocyte-monocyte progenitors.胚胎肥大细胞起源于表达Cpa3的前体细胞，而非粒细胞-单核细胞祖细胞。
Sci China Life Sci. 2025 May 22. doi: 10.1007/s11427-024-2891-1.
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Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets.组织巨噬细胞：起源、异质性、生物学功能、疾病及治疗靶点。
Signal Transduct Target Ther. 2025 Mar 7;10(1):93. doi: 10.1038/s41392-025-02124-y.
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Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.塑造免疫力：母体肠道细菌对胎儿免疫发育的影响。
Semin Immunopathol. 2025 Feb 1;47(1):13. doi: 10.1007/s00281-025-01039-8.
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NR2F6 regulates stem cell hematopoiesis and myelopoiesis in mice.NR2F6调节小鼠的干细胞造血和骨髓生成。
Front Immunol. 2025 Jan 7;15:1404805. doi: 10.3389/fimmu.2024.1404805. eCollection 2024.
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The Dual Role of Cellular Senescence in Macrophages: Unveiling the Hidden Driver of Age-Related Inflammation in Kidney Disease.细胞衰老在巨噬细胞中的双重作用：揭示肾脏疾病中与年龄相关炎症的隐藏驱动因素
Int J Biol Sci. 2025 Jan 1;21(2):632-657. doi: 10.7150/ijbs.104404. eCollection 2025.
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Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart.造血心形成类器官再现了人类造血系统和胚胎心脏的共同发育。
Nat Cell Biol. 2024 Nov;26(11):1984-1996. doi: 10.1038/s41556-024-01526-4. Epub 2024 Oct 8.
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Hematopoietic stem cell gene therapy to halt neurodegeneration.造血干细胞基因疗法可阻止神经退行性病变。
Neurotherapeutics. 2024 Jul;21(4):e00440. doi: 10.1016/j.neurot.2024.e00440. Epub 2024 Sep 14.
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Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells.长期植入由人类诱导多能干细胞分化而来的多谱系造血细胞。
Nat Biotechnol. 2024 Sep 2. doi: 10.1038/s41587-024-02360-7.
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Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming.脂肪组织巨噬细胞与生命早期代谢编程的关键问题与认识差距
Am J Physiol Endocrinol Metab. 2024 Oct 1;327(4):E478-E497. doi: 10.1152/ajpendo.00140.2024. Epub 2024 Aug 22.
本文引用的文献
1
Erythroid development in the mammalian embryo.哺乳动物胚胎中的红系发育。
Blood Cells Mol Dis. 2013 Dec;51(4):213-9. doi: 10.1016/j.bcmd.2013.07.006. Epub 2013 Aug 7.
2
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.Runx1 在造血祖细胞和干细胞中有不同的时间要求。
Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7.
3
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.小鼠胚胎外动脉血管中含有能够成熟为确定性 HSCs 的前体细胞。
Blood. 2013 Oct 3;122(14):2338-45. doi: 10.1182/blood-2012-12-470971. Epub 2013 Jul 17.
4
Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.鼠卵黄囊血管中白细胞募集的个体发生调控。
Blood. 2013 May 23;121(21):e118-28. doi: 10.1182/blood-2012-07-447144. Epub 2013 Mar 22.
5
Haemogenic endocardium contributes to transient definitive haematopoiesis.血发生心内膜有助于短暂的终末性造血。
Nat Commun. 2013;4:1564. doi: 10.1038/ncomms2569.
6
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.小胶质细胞通过 Pu.1 和 Irf8 依赖的途径从红系髓样前体细胞中出现。
Nat Neurosci. 2013 Mar;16(3):273-80. doi: 10.1038/nn.3318. Epub 2013 Jan 20.
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Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.涉及 Hedgehog、Notch 和 Scl 的信号轴促进胚胎内皮细胞向造血细胞的转变。
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E141-50. doi: 10.1073/pnas.1214361110. Epub 2012 Dec 12.
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Immature hematopoietic stem cells undergo maturation in the fetal liver.未成熟的造血干细胞在胎肝中经历成熟过程。
Development. 2012 Oct;139(19):3521-30. doi: 10.1242/dev.079210. Epub 2012 Aug 16.
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Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.Scl 抑制拟血细胞内皮和心内膜中的心肌生成。
Cell. 2012 Aug 3;150(3):590-605. doi: 10.1016/j.cell.2012.06.026.
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The puzzling origin of lymphocytes.淋巴细胞令人费解的起源。
Blood. 2012 Jun 14;119(24):5609-10. doi: 10.1182/blood-2012-04-420737.
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