红骨髓祖细胞：在造血干细胞出现之前，胚胎中的“确定性”造血。
Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells.
机构信息
Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
出版信息
Blood Cells Mol Dis. 2013 Dec;51(4):220-5. doi: 10.1016/j.bcmd.2013.09.006. Epub 2013 Oct 2.
Abstract
Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes.
摘要
红骨髓祖细胞（EMP）是胚胎发育过程中造血系统形成之前造血的主要来源。在这篇综述中，我们总结了目前关于这种造血干细胞（HSC）独立的造血祖细胞波出现、命运和潜力的知识，重点是作为模型系统的鼠胚胎。更好地理解胚胎中造血出现的时空控制最终将提高我们从胚胎干细胞和诱导多能干细胞中获得造血干细胞和祖细胞以用于治疗目的的能力。
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本文引用的文献
1
Erythroid development in the mammalian embryo.哺乳动物胚胎中的红系发育。
Blood Cells Mol Dis. 2013 Dec;51(4):213-9. doi: 10.1016/j.bcmd.2013.07.006. Epub 2013 Aug 7.
2
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.Runx1 在造血祖细胞和干细胞中有不同的时间要求。
Development. 2013 Sep;140(18):3765-76. doi: 10.1242/dev.094961. Epub 2013 Aug 7.
3
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.小鼠胚胎外动脉血管中含有能够成熟为确定性 HSCs 的前体细胞。
Blood. 2013 Oct 3;122(14):2338-45. doi: 10.1182/blood-2012-12-470971. Epub 2013 Jul 17.
4
Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.鼠卵黄囊血管中白细胞募集的个体发生调控。
Blood. 2013 May 23;121(21):e118-28. doi: 10.1182/blood-2012-07-447144. Epub 2013 Mar 22.
5
Haemogenic endocardium contributes to transient definitive haematopoiesis.血发生心内膜有助于短暂的终末性造血。
Nat Commun. 2013;4:1564. doi: 10.1038/ncomms2569.
6
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.小胶质细胞通过 Pu.1 和 Irf8 依赖的途径从红系髓样前体细胞中出现。
Nat Neurosci. 2013 Mar;16(3):273-80. doi: 10.1038/nn.3318. Epub 2013 Jan 20.
7
Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition.涉及 Hedgehog、Notch 和 Scl 的信号轴促进胚胎内皮细胞向造血细胞的转变。
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E141-50. doi: 10.1073/pnas.1214361110. Epub 2012 Dec 12.
8
Immature hematopoietic stem cells undergo maturation in the fetal liver.未成熟的造血干细胞在胎肝中经历成熟过程。
Development. 2012 Oct;139(19):3521-30. doi: 10.1242/dev.079210. Epub 2012 Aug 16.
9
Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.Scl 抑制拟血细胞内皮和心内膜中的心肌生成。
Cell. 2012 Aug 3;150(3):590-605. doi: 10.1016/j.cell.2012.06.026.
10
The puzzling origin of lymphocytes.淋巴细胞令人费解的起源。
Blood. 2012 Jun 14;119(24):5609-10. doi: 10.1182/blood-2012-04-420737.
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