哺乳动物胚胎中的红系发育。
Erythroid development in the mammalian embryo.
机构信息
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
出版信息
Blood Cells Mol Dis. 2013 Dec;51(4):213-9. doi: 10.1016/j.bcmd.2013.07.006. Epub 2013 Aug 7.
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.
红细胞生成是指红细胞祖细胞产生和终末分化的过程。在所有脊椎动物中，两种形态上不同的红系谱系（原始的、胚胎的和确定的、胎儿/成人的）在卵黄囊、胎儿肝脏和骨髓中依次形成，对于正常发育是必不可少的。红细胞在氧气运输、抗氧化防御和血管重塑方面具有高度特化的功能。在这里，我们综述了哺乳动物红细胞发育的个体发生的关键特征，强调了遗传和基因表达谱研究揭示的相似性和差异，并讨论了鉴定不同发育和分化阶段的红细胞的方法。
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