氨甲环酸对初次全髋关节置换术输血率的影响。
The effect of tranexamic acid on transfusion rate in primary total hip arthroplasty.
机构信息
Carilion Clinic Orthopaedics, Roanoke, Virginia.
Medical University of South Carolina Department of Orthopaedic Surgery, Charleston, South Carolina; Human and Health Performance; College of Charleston, Charleston, South Carolina.
出版信息
J Arthroplasty. 2014 Feb;29(2):387-9. doi: 10.1016/j.arth.2013.05.026. Epub 2013 Jun 21.
Total hip arthroplasty (THA) may produce blood loss requiring allogenic blood transfusion. Recently several authors have reported success decreasing their transfusion rate with tranexamic acid (TXA). We retrospectively reviewed our last 1595 primary THA in 1494 patients looking at whether the patients received TXA via IV infusion, topical application, or neither, and the need for a blood transfusion. Infusion of TXA acid produced a statistically significant difference in transfusion rate (p<0.001) while topical TXA failed to reach statistical significance (P=0.15). The transfusion rate without TXA was 19.86%, 4.39% with TXA infusion (odds ratio=5.36), and 12.86% (odds ratio=1.67) with topical TXA.
全髋关节置换术（THA）可能会导致需要异体输血的失血。最近，有几位作者报告称，使用氨甲环酸（TXA）成功降低了输血率。我们回顾性分析了最近 1494 例 1595 例初次 THA 的患者，观察了患者是否通过静脉输注、局部应用或不应用 TXA 以及是否需要输血。TXA 酸的输注在输血率方面产生了统计学上的显著差异（p<0.001），而局部 TXA 未达到统计学意义（P=0.15）。不使用 TXA 的输血率为 19.86%，使用 TXA 输注的输血率为 4.39%（优势比=5.36），使用局部 TXA 的输血率为 12.86%（优势比=1.67）。
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