Traverso L W
Resuscitation. 1985 Mar;12(4):271-7. doi: 10.1016/0300-9572(85)90008-5.
Minced pancreas or a collagenase solution alone had no effect on blood pressure when infused into experimental animals. However, collagenase digested fragments or the digested pancreatic supernatant (PSF) produces profound hypotension. Previously we have shown that aprotinin, a proteolytic enzyme inhibitor, successfully blocked PSF-induced hypotension in the pig but did not alter this hypotension in the dog or monkey. Species variability of aprotinin blockade was further investigated by infusing PSF from either the pig, dog, or monkey into five animals of the other two species ("across species"). PSF alone produced hypotension in every animal "across species" but PSF "across species" and in combination with aprotinin did not produce a hypotensive reaction in each "across species" combination. These species differences of the aprotinin blockade should be considered when seeking reasons why aprotinin has not proven effective in preventing the morbidity and mortality of human pancreatitis.
将切碎的胰腺或单独的胶原酶溶液注入实验动物体内时，对血压没有影响。然而，胶原酶消化的片段或消化后的胰腺上清液（PSF）会导致严重的低血压。此前我们已经表明，蛋白酶抑制剂抑肽酶成功地阻断了猪体内PSF诱导的低血压，但对狗或猴子的这种低血压没有影响。通过将来自猪、狗或猴子的PSF注入另外两个物种的五只动物体内（“跨物种”），进一步研究了抑肽酶阻断的物种变异性。单独的PSF在每只“跨物种”动物中都会导致低血压，但“跨物种”的PSF与抑肽酶联合使用时，在每种“跨物种”组合中都不会产生降压反应。在探究抑肽酶未能有效预防人类胰腺炎的发病率和死亡率的原因时，应考虑抑肽酶阻断的这些物种差异。
