Department of Mechanical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
J Mech Behav Biomed Mater. 2014 Jan;29:177-89. doi: 10.1016/j.jmbbm.2013.08.030. Epub 2013 Sep 16.
The mechanical response of human metatarsal bones is of importance in both research and clinical practice, especially when associated with the correction of Hallux Valgus. Verified and validated patient-specific finite-element analysis (FEA) based on CT scans developed for human femurs are extended here to the first and second metatarsal bones. Two fresh-frozen metatarsal #1 and five metatarsal #2 bones from three donors were loaded in-vitro at three different angles. Holes typical to Hallux Valgus correction were then drilled in the bones, which were reloaded until fracture. In parallel, high-order FE models of the bones were created from CT-scans that mimic the experimental setting. We validated the FE results by comparison to experimental observations. Excellent agreement was obtained with R(2)=0.97 and slope of the regression line close to 1. We also compared the FE predicted fracture load and location for the second metatarsal bones with these measured in the experiment, demonstrating an excellent prediction within 10% difference. After validation of the FE predictions, they were used to investigate the effect of drilled hole position, dimension and the insertion of a metallic device on the mechanical response so to optimize the outcome of the Hallux Valgus correction. This study further substantiates the potential use of FEA in clinical practice.
人跖骨的力学响应在研究和临床实践中都很重要，特别是在与治疗拇外翻相关联的时候。本研究基于股骨的 CT 扫描，对验证和验证的患者特异性有限元分析（FEA）进行了扩展，将其扩展到第一和第二跖骨。从三个供体中取出两个新鲜冷冻的跖骨 1 和五个跖骨 2，在三个不同的角度下进行体外加载。然后在骨骼上钻出典型的拇外翻矫正孔，然后重新加载直至骨折。同时，从模拟实验设置的 CT 扫描中创建了骨骼的高阶 FE 模型。我们通过与实验观察结果进行比较来验证 FE 结果。FE 结果与实验观察结果非常吻合，R（2）=0.97，回归线斜率接近 1。我们还比较了第二跖骨的 FE 预测骨折载荷和位置与实验中测量的结果，表明在 10%差异范围内具有很好的预测能力。在验证了 FE 预测结果后，我们使用它们来研究钻孔位置、尺寸和金属器械插入对机械响应的影响，以优化拇外翻矫正的结果。这项研究进一步证实了 FEA 在临床实践中的潜在应用。
