Koszta György, Fülesdi Béla
Debreceni Egyetem, Orvos- és Egészségtudományi Centrum Aneszteziológiai és Intenzív Terápiás Tanszék Debrecen Nagyerdei krt. 98. 4032.
Orv Hetil. 2013 Oct 13;154(41):1621-7. doi: 10.1556/OH.2013.29727.
Selenium deficiency results in profound changes in cellular defence mechanisms against oxidative stress, which plays an important role in the development of cardiovascular disease and the associated risk factors. Increased formation and decreased elimination of reactive oxygen radicals contribute to the complicated mechanisms of sepsis and related disorders. Use of selenium in prevention and treatment of the above mentioned conditions is not a new idea, but controversial data were published in relation to both fields recently. The aim of the present review is to summarize the most important results related to this area.
硒缺乏会导致细胞抗氧化应激防御机制发生深刻变化，而抗氧化应激在心血管疾病的发展及相关危险因素中起着重要作用。活性氧自由基生成增加和清除减少促成了脓毒症及相关病症的复杂机制。使用硒来预防和治疗上述病症并非新观点，但近期在这两个领域均发表了存在争议的数据。本综述的目的是总结与此领域相关的最重要结果。
