Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel; Strauss-Water, R&D Labs, Petach Tikva, Israel.
J Control Release. 2013 Dec 28;172(3):634-40. doi: 10.1016/j.jconrel.2013.09.018. Epub 2013 Oct 2.
Iodinated polyurethane (IPU) sponges were prepared by immersing sponges in aqueous/organic solutions of iodine or exposing sponges to iodine vapors. Iodine was readily adsorbed into the polymers up to 100% (w/w). The adsorption of iodine on the surface was characterized by XPS and SEM analyses. The iodine loaded IPU sponges were coated with ethylene vinyl acetate (EVA), in order to release iodine in a controlled rate for water decontamination combined with active carbon cartridge, which adsorbs the iodine residues after the microbial inactivation. The EVA coated IPU were incorporated in a water purifier and tested for iodine release to water and for microbial inactivation efficiency according to WQA certification program against P231/EPA for 250l, using 25l a day with flow rate of 6-8min/1l. The antimicrobial activity was also studied against Escherichia coli and MS2 phage. Bacterial results exceeded the minimal requirement for bacterial removal of 6log reduction throughout the entire lifespan. At any testing point, no bacteria was detected in the outlet achieving more than 7.1 to more than 8log reduction as calculated upon the inlet concentration. Virus surrogate, MS2, reduction results varied from 4.11log reduction under tap water, and 5.11log reduction under basic water (pH9) to 1.32 for acidic water (pH5). Controlled and stable iodine release was observed with the EVA coated IPU sponges and was effective in deactivating the bacteria and virus present in the contaminated water and thus, these iodinated PU systems could be used in water purification to provide safe drinking water. These sponges may find applications as disinfectants in medicine.
碘聚氨酯（IPU）海绵通过将海绵浸入碘的水/有机溶液或暴露于碘蒸气中来制备。碘很容易被吸附到聚合物中，最高可达 100%（重量/重量）。通过 XPS 和 SEM 分析对碘在表面的吸附进行了表征。为了在与活性炭筒结合进行水净化时以受控的速率释放碘，以吸附微生物失活后的碘残留物，将负载碘的 IPU 海绵涂覆乙烯-醋酸乙烯酯（EVA）。EVA 涂覆的 IPU 被纳入水净化器中，并根据 WQA 认证计划，按照 P231/EPA 针对 250l 进行了碘释放测试和微生物失活效率测试，每天使用 25l，流速为 6-8min/1l。还研究了对大肠杆菌和 MS2 噬菌体的抗菌活性。细菌结果超过了整个寿命期间去除 6log 减少的最小细菌去除要求。在任何测试点，在出口处都没有检测到细菌，在入口浓度的基础上计算出超过 7.1 到超过 8log 的减少。病毒替代物 MS2 的减少结果在自来水中为 4.11log 减少，在碱性水中（pH9）为 5.11log 减少，在酸性水中（pH5）为 1.32。观察到 EVA 涂覆的 IPU 海绵具有受控和稳定的碘释放，并能有效灭活污染水中存在的细菌和病毒，因此，这些碘化 PU 系统可用于水净化，以提供安全饮用水。这些海绵在医学上可能用作消毒剂。
