Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
Department of Mechanical Engineering, Indian Institute of Technology Delhi, New Delhi, 110016, India.
J Mater Chem B. 2024 Jun 19;12(24):5907-5916. doi: 10.1039/d4tb00439f.
Voice prostheses are known to fail in few weeks to several months of implantation due to the clogging mainly caused by microbial biofilm formation, which is a cause of concern. Iodine is a known broad-spectrum biocide and is reported to easily form complexes with various polymers. For long term device disinfection, strong iodine complexation that offers sustained iodine release for a prolonged period is essential. The present research work deals with the synthesis of a poly(methyl methacrylate--butyl acrylate--vinyl-2-pyrrolidone) (poly[MMA-BA-NVP]) tercopolymer through free radical polymerization for surface coating thermoplastic polyurethane (TPU) based voice prostheses. The NVP content in the tercopolymer was varied from 20% to 50% to optimise iodine loading and subsequent release. Base TPU coated with the tercopolymer was treated with 4% aqueous iodine solution at room temperature (28 ± 3 °C) for two hours. It was observed that the tercopolymer containing 35% -vinyl-2-pyrrolidone (NVP), 32.5% methyl methacrylate (MMA) and 32.5% butyl acrylate (BA) gave a stable coating on TPUs together with sustained iodine release for a prolonged period. Furthermore, the tercopolymer coated and iodine loaded TPUs exhibited excellent antimicrobial activity against , and .
义齿假体在植入后数周到数月内失效的情况并不少见，主要是由于微生物生物膜的形成而导致的堵塞，这是一个令人关注的问题。碘是一种已知的广谱杀菌剂，据报道，它很容易与各种聚合物形成复合物。为了实现长期设备消毒，需要具有持续碘释放能力的强碘络合作用。本研究工作涉及通过自由基聚合合成聚（甲基丙烯酸甲酯-丙烯酸丁酯-乙烯基-2-吡咯烷酮）（聚[MMA-BA-NVP]）三元共聚物，用于对基于热塑性聚氨酯（TPU）的义齿假体进行表面涂层。通过改变三元共聚物中的 NVP 含量（从 20%到 50%），以优化碘的负载和随后的释放。用 4%的水溶液在室温（28±3°C）下处理涂有基本 TPU 的三元共聚物 2 小时。结果表明，含有 35% -乙烯基-2-吡咯烷酮（NVP）、32.5%甲基丙烯酸甲酯（MMA）和 32.5%丙烯酸丁酯（BA）的三元共聚物在 TPU 上形成了稳定的涂层，同时能够持续释放碘，持续时间较长。此外，涂覆有三元共聚物和负载碘的 TPU 对 、 和 表现出优异的抗菌活性。
