Jahnke U, Fischer E H, Alvord E C
Science. 1985 Jul 19;229(4710):282-4. doi: 10.1126/science.2409602.
Post-infectious or post-vaccinal demyelinating encephalomyelitis and neuritis may be due to immunological cross-reactions evoked by specific viral antigenic determinants (epitopes) that are homologous to regions in the target myelins of the central and peripheral nervous systems. Such homologies have been found by computer searches in which decapeptides in two human myelin proteins were compared with proteins of viruses known to infect humans. These viruses include measles, Epstein-Barr, influenza A and B, and others that cause upper respiratory infections. Several regions identified in myelin basic protein and P2 protein can be related to experimental allergic encephalomyelitis or neuritis in laboratory animals.
感染后或疫苗接种后脱髓鞘性脑脊髓炎和神经炎可能是由于特定病毒抗原决定簇（表位）引发的免疫交叉反应所致，这些抗原决定簇与中枢和周围神经系统靶髓鞘中的区域同源。通过计算机搜索已发现了此类同源性，其中将两种人类髓鞘蛋白中的十肽与已知感染人类的病毒蛋白进行了比较。这些病毒包括麻疹病毒、爱泼斯坦-巴尔病毒、甲型和乙型流感病毒以及其他引起上呼吸道感染的病毒。在髓鞘碱性蛋白和P2蛋白中鉴定出的几个区域可能与实验性变应性脑脊髓炎或实验室动物的神经炎有关。
