Domschke W, Domschke S
Klin Wochenschr. 1975 Sep 15;53(18):841-6. doi: 10.1007/BF01466956.
The criteria to determine whether cyclic adenosine 3':5'-monophosphate (cyclic AMP) is or is not involved in a particular hormone response require to look for positive qualitive, quantitative and temporal correlations between the effects of the hormone on cyclic AMP levels and the physiological response. These requirements have been shown to be fulfilled in histamine and pentagastrin-stimulated gastric acid secretion of the frog (Necturus maculosus) and the rat. In dog and man, however, the available evidence does not support a role for cyclic AMP in the gastric secretory process; it remains a challenge for future research whether in those species cyclic guanosine 3':5'-monophosphate acts as an intracellular substitute for cyclic AMP.
确定环磷腺苷（cAMP）是否参与特定激素反应的标准，需要寻找激素对cAMP水平的影响与生理反应之间在性质、数量和时间上的正相关关系。这些要求已在组胺和五肽胃泌素刺激的青蛙（黄斑美西螈）和大鼠胃酸分泌中得到满足。然而，在狗和人类中，现有证据并不支持cAMP在胃分泌过程中起作用；对于这些物种中，环鸟苷酸是否作为cAMP的细胞内替代物，仍是未来研究的一个挑战。
