Cooke A R, Preshaw R M, Grossman M L
Gastroenterology. 1966 Jun;50(6):761-7.
The effect of bilateral adrenalectomy on the secretion and absorption of acid in Heidenhain pouch dogs has been investigated. It was found that bilateral adrenalectomy significantly decreased the acid output to varying doses of histamine and did not alter the relation between hydrogen ion concentration and the volume rate of secretion. The absorption of acid by the gastric mucosa was not changed by adrenalectomy. Glucocorticoids but not mineralocorticoids restored secretion to normal levels. These experiments indicate that the impaired secretion of acid in response to histamine in adrenalectomized dogs is not attributable to increased leakage of secreted acid from lumen to blood.
已经研究了双侧肾上腺切除术对海登海因小胃犬胃酸分泌和吸收的影响。发现双侧肾上腺切除术显著降低了对不同剂量组胺的酸分泌量，并且没有改变氢离子浓度与分泌量之间的关系。肾上腺切除术并未改变胃黏膜对酸的吸收。糖皮质激素而非盐皮质激素可使分泌恢复到正常水平。这些实验表明，肾上腺切除犬对组胺反应时酸分泌受损并非由于分泌的酸从管腔向血液的渗漏增加所致。
