Department of Biomedical Engineering, University of Kentucky, Lexington, KY 40506-0070, USA.
Acta Biomater. 2014 Jan;10(1):115-25. doi: 10.1016/j.actbio.2013.09.031. Epub 2013 Oct 1.
Because many complex physiological processes are controlled by multiple biomolecules, comprehensive treatment of certain disease conditions may be more effectively achieved by administration of more than one type of drug. Thus, the objective of the present research was to develop a multilayered, polymer-based system for sequential delivery of multiple drugs. The polymers used were cellulose acetate phthalate (CAP) complexed with Pluronic F-127 (P). After evaluating morphology of the resulting CAPP system, in vitro release of small molecule drugs and a model protein was studied from both single and multilayered devices. Drug release from single-layered CAPP films followed zero-order kinetics related to surface erosion of the association polymer. Release studies from multilayered CAPP devices showed the possibility of achieving intermittent release of one type of drug as well as sequential release of more than one type of drug. Mathematical modeling accurately predicted the release profiles for both single layer and multilayered devices. The present CAPP association polymer-based multilayer devices can be used for localized, sequential delivery of multiple drugs for the possible treatment of complex disease conditions, and perhaps for tissue engineering applications, that require delivery of more than one type of biomolecule.
由于许多复杂的生理过程受到多种生物分子的控制，因此通过给予多种类型的药物来综合治疗某些疾病状况可能更为有效。因此，本研究的目的是开发一种基于聚合物的多层系统，用于顺序递送多种药物。所使用的聚合物为与泊洛沙姆 F-127（P）复合的邻苯二甲酸醋酸纤维素（CAP）。在评估所得的 CAPP 系统的形态之后，从小分子药物和模型蛋白的单层和多层装置研究了体外药物释放。单层 CAPP 薄膜的药物释放遵循与缔合聚合物表面侵蚀相关的零级动力学。多层 CAPP 装置的释放研究表明，有可能实现一种药物的间歇性释放以及超过一种药物的顺序释放。数学模型准确地预测了单层和多层装置的释放曲线。基于 present CAPP 缔合聚合物的多层装置可用于局部、顺序递送多种药物，以治疗可能需要递送多种生物分子的复杂疾病状况，也许还可用于组织工程应用。
