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多种药物从柔性给药薄膜中的顺序释放。

Sequential Release of Multiple Drugs from Flexible Drug Delivery Films.

作者信息

Jennings Cheryl L, Perry Ellis K, Dziubla Thomas D, Puleo David A

机构信息

Department of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.

出版信息

Int J Polym Mater. 2017;66(11):569-576. doi: 10.1080/00914037.2016.1252352. Epub 2017 Jan 4.

DOI:10.1080/00914037.2016.1252352
PMID:28736462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5515595/
Abstract

Sequential release of drugs aligned with the phases of tissue healing could reduce scarring. To achieve this aim, layered film devices comprising cellulose acetate phthalate (CAP) and Pluronic F-127 (Pluronic) were loaded with ketoprofen, quercetin, and pirfenidone. Citrate plasticizers were added to impart flexibility. Release of two or three drugs in sequence over several days was obtained for all multilayered devices tested. Mechanical analysis showed that elongation increased and modulus decreased with increasing plasticizer content. Release profiles can be tailored by order of layers, plasticizer concentration, and drug loaded, making CAP-Pluronic an appealing system for inhibiting scar tissue formation.

摘要

与组织愈合阶段同步释放药物可以减少瘢痕形成。为实现这一目标，将酮洛芬、槲皮素和吡非尼酮负载于由邻苯二甲酸醋酸纤维素（CAP）和泊洛沙姆F - 127（泊洛沙姆）组成的分层薄膜装置中。添加柠檬酸盐增塑剂以赋予柔韧性。对于所有测试的多层装置，均实现了两种或三种药物在数天内的顺序释放。力学分析表明，随着增塑剂含量的增加，伸长率增加而模量降低。释放曲线可通过层序、增塑剂浓度和药物负载量进行调整，这使得CAP - 泊洛沙姆成为抑制瘢痕组织形成的有吸引力的系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/0ffb9b148547/nihms879300f10.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/b4c9d0162f11/nihms879300f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/73cb1bb5a2bd/nihms879300f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/0ffb9b148547/nihms879300f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/35eea525a3a0/nihms879300f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/68e78da409db/nihms879300f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/b20c66433717/nihms879300f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/2cb0df344f23/nihms879300f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/b035d109242c/nihms879300f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/62be248563f5/nihms879300f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/9108c6b5a199/nihms879300f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/b4c9d0162f11/nihms879300f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/73cb1bb5a2bd/nihms879300f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf3/5515595/0ffb9b148547/nihms879300f10.jpg

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