Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia,
Protein J. 2013 Oct;32(7):505-11. doi: 10.1007/s10930-013-9514-1.
The limited sequence similarity of protein sequences with known structures has led to an indispensable need for computational technology to predict their structures. Structural bioinformatics (SB) has become integral in elucidating the sequence-structure-function relationship of a protein. This report focuses on the applications of SB within the context of protein engineering including its limitation and future challenges.
已知结构的蛋白质序列的有限序列相似性导致了对计算技术预测其结构的不可或缺的需求。结构生物信息学（SB）已经成为阐明蛋白质序列-结构-功能关系的不可或缺的部分。本报告重点介绍了 SB 在蛋白质工程中的应用，包括其局限性和未来挑战。
