Hayney Mary S, Coe Christopher L, Muller Daniel, Obasi Chidi N, Backonja Uba, Ewers Tola, Barrett Bruce
School of Pharmacy; University of Wisconsin-Madison; Madison, WI USA.
Harlow Center for Biological Psychology; University of Wisconsin-Madison; Madison, WI USA.
Hum Vaccin Immunother. 2014;10(1):83-91. doi: 10.4161/hv.26661. Epub 2013 Oct 7.
Strategies to improve influenza vaccine protection among elderly individuals are an important research priority. Mindfulness-based stress reduction (MBSR) and exercise have been shown to affect aspects of immune function in some populations. We hypothesized that influenza vaccine responses may be enhanced with meditation or exercise training as compared with controls.
No differences in vaccine responses were found comparing control to MBSR or exercise. Individuals achieving seroprotective levels of influenza antibody ≥160 units had higher optimism, less anxiety, and lower perceived stress than the nonresponders. Age correlated with influenza antibody responses, but not with IFNγ or IL-10 production.
The MBSR and exercise training evaluated in this study failed to enhance immune responses to influenza vaccine. However, optimism, perceived stress, and anxiety were correlated in the expected directions with antibody responses to influenza vaccine.
Healthy individuals≥50 y were randomly assigned to exercise (n=47) or MBSR (n=51) training or a waitlist control condition (n=51). Each participant received trivalent inactivated influenza vaccine after 6 weeks, and had blood draws prior to and 3 and 12 weeks after immunization. Serum influenza antibody, nasal immunoglobulin A, and peripheral blood mononuclear cell interferon-γ (IFNγ) and interleukin-10 (IL-10) concentrations were measured. Measures of optimism, perceived stress, and anxiety were obtained over the course of the study. Seroprotection was defined as an influenza antibody concentration≥160 units. Vaccine responses were compared using ANOVA, t tests, and Kruskal-Wallis tests. The correlation between vaccine responses and age was examined with the Pearson test.
改善老年人流感疫苗保护效果的策略是一项重要的研究重点。基于正念的减压疗法（MBSR）和运动已被证明会影响某些人群的免疫功能。我们假设与对照组相比，冥想或运动训练可能会增强流感疫苗反应。
将对照组与MBSR组或运动组进行比较，未发现疫苗反应存在差异。达到流感抗体血清保护水平≥160单位的个体比无反应者更乐观、焦虑更少且感知压力更低。年龄与流感抗体反应相关，但与干扰素γ（IFNγ）或白细胞介素10（IL-10）的产生无关。
本研究中评估的MBSR和运动训练未能增强对流感疫苗的免疫反应。然而，乐观、感知压力和焦虑与流感疫苗抗体反应在预期方向上相关。
将年龄≥50岁的健康个体随机分配至运动组（n = 47）、MBSR组（n = 51）或候补对照条件组（n = 51）。每位参与者在6周后接种三价灭活流感疫苗，并在免疫前、免疫后3周和12周进行采血。测量血清流感抗体、鼻免疫球蛋白A以及外周血单核细胞干扰素γ（IFNγ）和白细胞介素10（IL-10）的浓度。在研究过程中获取乐观、感知压力和焦虑的测量值。血清保护定义为流感抗体浓度≥160单位。使用方差分析、t检验和克鲁斯卡尔 - 沃利斯检验比较疫苗反应。通过Pearson检验检查疫苗反应与年龄之间的相关性。
