1Division of Reproductive Biology, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA.
Reprod Sci. 2014 May;21(5):582-9. doi: 10.1177/1933719113506498. Epub 2013 Oct 4.
To quantify the number of follicles in patients with ovarian pathologies, benign and malignant, in pregnant and nonpregnant states and to determine how the presence of ovarian masses and BRCA status affects follicular counts.
Slides from 134 reproductive-aged women undergoing oophorectomy were examined using light microscopy by 3 independent counters blinded to the diagnosis. In all, 20 patients had cancer, 69 had benign conditions, and 35 patients were BRCA+ or had a strong family history of breast and/or ovarian cancer. In all, 10 women were either pregnant or immediately postpartum.
Patients undergoing risk-reducing surgery had significantly decreased follicle count compared to physiologic control. Patients with cancer had significantly decreased counts compared to all other groups. There were no differences within the benign cohort.
When compared to benign masses, the cortex surrounding an ovarian malignancy has decreased follicle density. The stretch impact may minimize any impact on total follicle numbers. Furthermore, there may be a proliferation of ovarian stroma, with the same number of follicles spread over a larger surface area. This information is important when counseling women with ovarian masses regarding the use of ovarian tissue cryopreservation.
定量分析妊娠和非妊娠状态下患有卵巢良、恶性病变患者的卵泡数量，并确定卵巢肿块的存在和 BRCA 状态如何影响卵泡计数。
对 134 名接受卵巢切除术的育龄妇女的切片进行了研究，由 3 名独立的计数器使用显微镜进行检查，这些计数器对诊断结果一无所知。共有 20 名患者患有癌症，69 名患者患有良性疾病，35 名患者 BRCA+或有强烈的乳腺癌和/或卵巢癌家族史。共有 10 名女性处于妊娠或产后状态。
与生理对照组相比，进行风险降低手术的患者卵泡计数明显减少。与所有其他组相比，癌症患者的计数明显减少。良性组内无差异。
与良性肿块相比，卵巢恶性肿瘤周围的皮质卵泡密度降低。拉伸的影响可能会最小化对总卵泡数量的任何影响。此外，可能会出现卵巢间质的增殖，相同数量的卵泡分布在更大的表面积上。当向患有卵巢肿块的女性提供关于卵巢组织冷冻保存的咨询时，这些信息非常重要。
