Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
J Pharmacol Sci. 2013;123(2):199-202. doi: 10.1254/jphs.13122sc. Epub 2013 Oct 4.
We investigated whether milnacipran, a serotonin-noradrenaline reuptake inhibitor, exhibits an antipruritic effect through the spinal action in mice. Intrathecal injections of milnacipran (0.1 - 10 μg/site) significantly suppressed serotonin-induced biting, which is an itch-related response. However, such an effect was not observed with fluvoxamine (10 μg/site), which is a selective serotonin reuptake inhibitor. Furthermore, an intraperitoneal injection of milnacipran (10 mg/kg) inhibited serotonin-induced biting. When phentolamine (1.0 μg/site), a non-selective α-adrenoceptor antagonist, was intrathecally injected, it inhibited the above response of milnacipran. These results suggest that milnacipran suppresses itching through the inhibition of noradrenaline reuptake in the spinal cord.
我们研究了米那普仑（一种 5-羟色胺-去甲肾上腺素再摄取抑制剂）是否通过脊髓作用在小鼠中表现出止痒作用。鞘内注射米那普仑（0.1-10μg/部位）可显著抑制 5-羟色胺诱导的咬，这是一种与瘙痒相关的反应。然而，在用选择性 5-羟色胺再摄取抑制剂氟伏沙明（10μg/部位）处理时，未观察到这种作用。此外，米那普仑（10mg/kg）的腹腔内注射抑制了 5-羟色胺诱导的咬。当鞘内注射非选择性α-肾上腺素受体拮抗剂酚妥拉明（1.0μg/部位）时，它抑制了米那普仑的上述反应。这些结果表明，米那普仑通过抑制脊髓中的去甲肾上腺素再摄取来抑制瘙痒。
