Ashida Miwa, Murayama Naoya, Kamio Yoshiyuki, Yozaki Mariko, Kuwatsuka Yutaka, Nakahara Takeshi, Murota Hiroyuki
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, Fukuoka, Japan.
J Dermatol. 2025 May;52(5):934-938. doi: 10.1111/1346-8138.17689. Epub 2025 Mar 3.
Yusho, a dioxin poisoning incident in Japan, has resulted in patients experiencing persistent symptoms, including sensory disturbances, decades after the initial exposure. This study investigated the potential involvement of the descending pain inhibitory system in Yusho patients. Serum serotonin, dopamine, and norepinephrine levels were measured in 29 Yusho patients and 29 age-matched healthy controls. No significant differences in these neurotransmitters were observed between the two groups. However, weak correlations were found between polychlorinated biphenyl levels and dopamine (r = 0.4310, p = 0.0315) in Yusho patients. This study provides new insights into the pathophysiology of cutaneous sensory disorders and highlights the need for further research to clarify the long-term effects of dioxin exposure on Yusho patients.
“油症”是日本发生的一起二噁英中毒事件，导致患者在初次接触后的数十年间一直出现包括感觉障碍在内的持续性症状。本研究调查了下行性疼痛抑制系统在“油症”患者中的潜在作用。对29名“油症”患者和29名年龄匹配的健康对照者测量了血清5-羟色胺、多巴胺和去甲肾上腺素水平。两组之间在这些神经递质方面未观察到显著差异。然而，在“油症”患者中发现多氯联苯水平与多巴胺之间存在弱相关性（r = 0.4310，p = 0.0315）。本研究为皮肤感觉障碍的病理生理学提供了新的见解，并强调需要进一步研究以阐明二噁英暴露对“油症”患者的长期影响。
