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儿童基因检测。

Genetic testing in children.

机构信息

Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Correspondence to: Dr Shubha Rajendra Phadke, Head of the Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rai Bareilley Road, Lucknow 226 001, Uttar Pradesh, India.

出版信息

Indian Pediatr. 2013 Sep;50(9):823-7. doi: 10.1007/s13312-013-0228-4.

Abstract

Increasing availability of DNA based tests in clinical practice has lead to widespread debate on the ethical issues involved. The wider usage of these tests in children has raised many questions regarding the ethics, validity of the request and its effects on childs psychosocial well-being. Though there have been much discussion with many studies attempting to address the issue, there is no consensus. Formulation of guidelines has been hampered by the diversity of tests available for varied indications and lack of research studying the effects of testing in children over a time. Some tests have valid indications with proven benefits over harms while others have less clear justification. We attempt to address this issue with the intent to sensitize the caregivers regarding various aspects to be considered before offering any genetic tests in children.

摘要

随着 DNA 检测在临床实践中的广泛应用,引发了广泛的伦理问题讨论。这些检测在儿童中的广泛应用引发了许多关于伦理、请求的有效性及其对儿童心理社会健康影响的问题。尽管已经进行了大量的讨论,并进行了许多研究来试图解决这个问题,但仍未达成共识。由于可供选择的检测方法多种多样,并且缺乏研究检测对儿童的长期影响,因此制定指南受到了阻碍。一些检测有明确的适应证,其益处超过了危害,而其他检测则没有那么明确的依据。我们试图解决这个问题,旨在让照顾者关注在为儿童提供任何基因检测之前需要考虑的各个方面。

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