Hassan H G, Renck H, Lindberg B, Lindquist B, Akerman B
Acta Anaesthesiol Scand. 1985 May;29(4):380-3. doi: 10.1111/j.1399-6576.1985.tb02219.x.
The effects of adding various macromolecular substances to 2% prilocaine on duration of rat infraorbital nerve block were investigated. The tested substances consisted of dextrans with lipophilic or charged substituents as well as other neutral or highly charged macromolecules. Most of the adjuvants caused significant prolongations of sensory block. For substituted dextrans the duration of sensory block degree 3 amounted to between 120% (3% capryldextran II) and 350% (3% carboxymethyldextran) in comparison to prilocaine plain. The corresponding values for hydroxypropylstarch (3%) alginic acid (0.5%), beta-cyclodextrin (1.5%) and hyaluronic acid (0.25%) were about 170%, 285% and 380%, respectively. The results suggest that the increased duration of local analgesia by prilocaine is related to increased viscosity of the solution produced by the macromolecular compounds. The mechanism seems to be of a physical character, and hyaluronic acid seems to be worthy of further studies.
研究了在2%丙胺卡因中添加各种大分子物质对大鼠眶下神经阻滞持续时间的影响。受试物质包括带有亲脂性或带电荷取代基的右旋糖酐以及其他中性或高电荷大分子。大多数佐剂导致感觉阻滞显著延长。与单纯丙胺卡因相比，对于取代右旋糖酐，3级感觉阻滞的持续时间在120%（3%辛酰右旋糖酐II）至350%（3%羧甲基右旋糖酐）之间。羟丙基淀粉（3%）、海藻酸（0.5%）、β-环糊精（1.5%）和透明质酸（0.25%）的相应值分别约为170%、285%和380%。结果表明，丙胺卡因局部镇痛持续时间的延长与大分子化合物产生的溶液粘度增加有关。其机制似乎具有物理性质，透明质酸似乎值得进一步研究。
