Hassan H G, Youssef H, Renck H
Faculty of Medicine, University of Kuwait, Safat, Kuwait-Arabian Gulf.
Acta Anaesthesiol Scand. 1993 Jan;37(1):70-4. doi: 10.1111/j.1399-6576.1993.tb03601.x.
The effects of bupivacaine-prilocaine and meperidine-lidocaine combinations (as compared with those of the agents used alone) on the duration of peripheral sensory nerve block were studied with the infraorbital nerve block model (IONB) in the rat, and those on motor block with spinal anesthesia (SA) in the mouse. The duration of bupivacaine-induced IONB was invariably prolonged when prilocaine was included in the solution. When included in 0.125% bupivacaine, 1.0% prilocaine had a slightly less pronounced enhancing effect than 0.5% prilocaine (24-57% vs. 74%-104%, respectively). The duration of IONB with 1.0% prilocaine was significantly reduced (14-37%) by inclusion of 0.125% bupivacaine. In SA, inclusion in 0.125% bupivacaine of prilocaine (0.5% or 1.0%) prolonged motor block by 128% and 192%, respectively. When included in 0.25% bupivacaine, both 0.5% and 1.0% prilocaine significantly reduced the duration of SA, by 42% and 37%, respectively. With one exception, the duration of IONB by meperidine was significantly shortened (< 44%) when lidocaine was included in the solution. In SA, inclusion of 2% lidocaine with 2% meperidine did not affect the duration of meperidine-induced motor block. The duration of SA obtained with the combination of 4% lidocaine and 4% meperidine was 45% shorter than that induced by 4% meperidine alone. The reasons for these variable effects are not clear, but may be due to interaction or antagonism at any of multiple sites.
采用大鼠眶下神经阻滞模型（IONB）研究了布比卡因-丙胺卡因和哌替啶-利多卡因联合用药（与单独使用药物相比）对外周感觉神经阻滞持续时间的影响，并采用小鼠脊髓麻醉（SA）模型研究了其对运动阻滞的影响。当溶液中加入丙胺卡因时，布比卡因诱导的IONB持续时间总是延长。当加入0.125%布比卡因中时，1.0%丙胺卡因的增强作用比0.5%丙胺卡因稍弱（分别为24%-57%和74%-104%）。加入0.125%布比卡因可使1.0%丙胺卡因的IONB持续时间显著缩短（14%-37%）。在SA中，0.125%布比卡因中加入丙胺卡因（0.5%或1.0%）可使运动阻滞时间分别延长128%和192%。当加入0.25%布比卡因中时，0.5%和1.0%丙胺卡因均显著缩短SA持续时间，分别缩短42%和37%。除一个例外，当溶液中加入利多卡因时，哌替啶诱导的IONB持续时间显著缩短（<44%）。在SA中，2%利多卡因与2%哌替啶联合使用不影响哌替啶诱导的运动阻滞持续时间。4%利多卡因与4%哌替啶联合使用获得的SA持续时间比单独使用4%哌替啶诱导的持续时间短45%。这些不同作用的原因尚不清楚，但可能是由于多个位点中的任何一个发生相互作用或拮抗作用所致。
