Department of Urology, University Hospital "Carl Gustav Carus", Dresden University of Technology, Fetscherstrasse 74, 01304, Dresden, Germany,
Drugs Aging. 2013 Dec;30(12):959-67. doi: 10.1007/s40266-013-0123-7.
There is no standard treatment for locally advanced prostate cancer. Even the definition is still unclear. Locally advanced disease may refer to over-staged well-curable tumors as well as to advanced and probably incurable cancers. Similar uncertainties are present regarding the definition of 'old' in this context. Conservatively treated locally advanced prostate cancer is associated with poor survival outcome. With the increasing life expectancy, in the absence of curative treatment, even patients in their ninth decade of life may later suffer from symptoms of aggressive prostate cancer and are at a high risk of death from prostate cancer that might be prevented at least in part by early intervention. On the other hand, functional results after prostate cancer treatment are worse in elderly patients. In this article we discuss aspects of the management of locally advanced prostate cancer in the elderly with special focus on the recommendation of current clinical guidelines.
局部晚期前列腺癌尚无标准治疗方法。即使是定义也仍不明确。局部晚期疾病可能是指分期过高但仍可治愈的肿瘤，以及晚期且可能无法治愈的癌症。在这种情况下，“老”的定义也存在类似的不确定性。局部晚期前列腺癌的保守治疗与不良生存结果相关。随着预期寿命的增加，在缺乏治愈性治疗的情况下，即使是 90 多岁的患者，以后也可能出现侵袭性前列腺癌的症状，并且死于前列腺癌的风险很高，这种风险至少可以部分通过早期干预来预防。另一方面，老年患者前列腺癌治疗后的功能结果更差。在本文中，我们讨论了老年局部晚期前列腺癌的治疗管理方面的问题，特别关注当前临床指南的建议。
