Leoutsakos A, Truneh A, Pearce F L
Agents Actions. 1985 Apr;16(3-4):126-8. doi: 10.1007/BF01983118.
Immunological activation of rat peritoneal mast cells induced a transient elevation in the intracellular concentration of cyclic AMP. Enhancement or suppression of this rise by appropriate adenosine analogues produced parallel changes in histamine secretion. However, pharmacological activation of the cell with a number of diverse ligands induced histamine release without any accompanying changes in cyclic AMP. Moreover, this release was modulated by adenosine analogues in identical fashion to IGE-directed ligands but again without affecting cyclic AMP. On the basis of these results, the possible role of cyclic AMP in the induction of histamine secretion is critically considered.
大鼠腹膜肥大细胞的免疫激活导致细胞内环磷酸腺苷（cAMP）浓度短暂升高。适当的腺苷类似物增强或抑制这种升高会使组胺分泌产生相应变化。然而，用多种不同配体对细胞进行药理学激活会诱导组胺释放，而cAMP却没有任何伴随变化。此外，这种释放受到腺苷类似物的调节，其方式与免疫球蛋白E（IgE）导向的配体相同，但同样不影响cAMP。基于这些结果，对cAMP在组胺分泌诱导中的可能作用进行了批判性思考。
