γ-氨基丁酸对体外过敏性组胺释放的抑制作用。
Inhibition of anaphylactic histamine release in vitro by GABA.
作者信息
Luzzi S, Franchi-Micheli S, Spagnesi S, Rosi E, Ciuffi M, Zilletti L
出版信息
Agents Actions. 1985 Apr;16(3-4):160-2. doi: 10.1007/BF01983127.
Inhibitory effect of GABA on anaphylactic histamine release in vitro is not mimicked by 2-aminoethansulphonic acid (taurine), an aminoacid unrelated to GABA neuro-transmission. Tetrodotoxin (TTX) 6 X 10(-7) M, a concentration known to block neuronal mechanism but not to modify muscle membrane and anaphylactic histamine release, strongly prevented the inhibition caused by GABA in the Schultz-Dale reaction and in anaphylactic histamine release. The inhibitory effect of GABA on anaphylactic reaction in vitro thus appears to be specific for this aminoacid and is neurogenic in nature, in that it requires integrity of neuronal mechanisms.
2-氨基乙磺酸（牛磺酸）是一种与γ-氨基丁酸（GABA）神经传递无关的氨基酸，它不能模拟GABA对体外过敏组胺释放的抑制作用。河豚毒素（TTX）浓度为6×10⁻⁷M，已知该浓度可阻断神经元机制，但不改变肌肉膜和过敏组胺释放，它强烈地阻止了GABA在舒尔茨-戴尔反应和过敏组胺释放中所引起的抑制作用。因此，GABA对体外过敏反应的抑制作用似乎对这种氨基酸具有特异性，并且本质上是神经源性的，因为它需要神经元机制的完整性。
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