豚鼠和大鼠不同组织在过敏反应期间释放的组胺和过敏反应迟缓反应物质的相对生物活性。
Relative bioactivity of histamine and slow reacting substance of anaphylaxis released during anaphylactic reaction from different tissues of guinea pigs and rats.
作者信息
Shahani S R, Dhar H L
机构信息
Department of Pharmacology, L.T.M. Medical College, Sion, Bombay.
出版信息
Indian J Physiol Pharmacol. 1987 Apr-Jun;31(2):107-10.
Relative amount of histamine and SRS-A released during Schultz Dale reaction were indirectly estimated. Percent block produced by specific antagonists, mepyramine and FPL 55712, on antigen induced response in various tissues was compared with controls. The relative bioactivity of histamine and SRS-A released was 93% and 7%, respectively, in rat lungs: 37% and 63% in guinea pig lungs; 82% and 18% in guinea pig intestine, 59% and 41% in rat intestine and 100% and 0% in skin of guinea pig and rats. Expectedly, individual experiments showed gross variations because anaphylaxis is rarely dose related.
舒尔茨-戴尔反应期间释放的组胺和慢反应物质A的相对量通过间接方法进行估算。将特异性拮抗剂美吡拉敏和FPL 55712对各种组织中抗原诱导反应产生的阻断百分比与对照组进行比较。在大鼠肺中，释放的组胺和慢反应物质A的相对生物活性分别为93%和7%；在豚鼠肺中为37%和63%；在豚鼠肠道中为82%和18%；在大鼠肠道中为59%和41%；在豚鼠和大鼠皮肤中为100%和0%。不出所料，由于过敏反应很少与剂量相关，个别实验显示出较大差异。
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