γ-氨基丁酸对体外过敏性组胺释放的影响。

Influence of GABA on anaphylactic histamine release in vitro.

作者信息

Zilletti L, Luzzi S, Franchi-Micheli S, Rizzotti M, Rosi E, Spagnesi S

出版信息

Agents Actions. 1984 Apr;14(3-4):478-80. doi: 10.1007/BF01973853.

DOI:10.1007/BF01973853

PMID:6203370

Abstract

In this preliminary report an unreported inhibitory action of GABA on anaphylactic reaction has been described. In a functional model (Schultz-Dale reaction) GABA has been demonstrated to inhibit the antigen-evoked contraction. This effect depends on a modulation of anaphylactic histamine release. The phenomenon is dose-dependent and requires a period of time to develop. Since GABAergic neurons are present in the preparation, it is possible to speculate that GABA receptors are involved in this inhibitory action. However, pharmacological analysis of the phenomenon has to be carried out, especially in view of the latency of GABA to develop its effect.

摘要

在本初步报告中，描述了γ-氨基丁酸（GABA）对过敏反应的一种未报道的抑制作用。在一个功能模型（舒尔茨-戴尔反应）中，已证明GABA能抑制抗原诱发的收缩。这种作用取决于对过敏反应中组胺释放的调节。该现象呈剂量依赖性，且需要一段时间来显现。由于制剂中存在γ-氨基丁酸能神经元，因此可以推测γ-氨基丁酸受体参与了这种抑制作用。然而，必须对该现象进行药理学分析，特别是考虑到γ-氨基丁酸发挥其作用的潜伏期。