遥远过去的回响：幽门螺杆菌的 cag 致病岛。
Echoes of a distant past: The cag pathogenicity island of Helicobacter pylori.
机构信息
Systems Biology Unit, Novartis Vaccines and Diagnostics, 53100 Siena, Italy.
出版信息
Cold Spring Harb Perspect Med. 2013 Nov 1;3(11):a010355. doi: 10.1101/cshperspect.a010355.
Abstract
This review discusses the multiple roles of the CagA protein encoded by the cag pathogenicity island of Helicobacter pylori and highlights the CagA degradation activities on p53. By subverting the p53 tumor suppressor pathway CagA induces a strong antiapoptotic effect. Helicobacter pylori infection has been always associated with an increased risk of gastric cancer. The pro-oncogenic functions of CagA also target the tumor suppressor ASPP2. In the absence of tumor suppressor genes, cells survive and proliferate at times and in places where their survival and proliferation are inappropriate.
摘要
本文讨论了幽门螺杆菌 cag 致病岛编码的 CagA 蛋白的多种作用，并强调了 CagA 对 p53 的降解活性。通过颠覆 p53 肿瘤抑制途径，CagA 诱导强烈的抗凋亡作用。幽门螺杆菌感染一直与胃癌风险增加相关。CagA 的致癌功能还针对肿瘤抑制因子 ASPP2。在没有肿瘤抑制基因的情况下，细胞在不适当的时间和地点存活和增殖。
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