Practical Guides Writing Group, Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA.
Otolaryngol Head Neck Surg. 2013 Dec;149(6):804-12. doi: 10.1177/0194599813506539. Epub 2013 Oct 4.
"Comparative effectiveness research" (CER) is not a new concept; however, recently it has been popularized as a method to develop scientifically sound actionable data by which patients, physicians, payers, and policymakers may make informed health care decisions. Fundamental to CER is that the comparative data are derived from large diverse populations of patients assembled from point-of-care general primary care practices and that measured outcomes include patient value judgments. The challenge is to obtain scientifically valid data to be acted upon by decision-making stakeholders with potentially quite diversely different agenda. The process requires very thoughtful research designs modulated by complex statistical and analytic methods. This article is composed of a guiding narrative with an extensive set of tables outlining many of the details required in performing and understanding CER. It ends with short discussions of three example papers, limitations of the method, and how a practicing physician may view such reports.
“比较效果研究”（CER）并不是一个新概念；然而，最近它已被推广为一种通过科学合理的可操作数据来帮助患者、医生、支付者和政策制定者做出明智的医疗保健决策的方法。CER 的基础是，比较数据源自从护理点收集的来自普通初级保健实践的大量不同患者群体，并且测量结果包括患者的价值判断。挑战在于获得科学有效的数据，以便由具有潜在差异很大的不同议程的决策利益相关者采取行动。该过程需要非常谨慎的研究设计，并通过复杂的统计和分析方法进行调整。本文由一个指导叙述和一系列广泛的表格组成，概述了执行和理解 CER 所需的许多细节。最后简短讨论了三篇示例论文、该方法的局限性以及执业医生如何看待此类报告。
