TGF-β：T 细胞功能的守护者。
TGF-β: guardian of T cell function.
机构信息
Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
出版信息
J Immunol. 2013 Oct 15;191(8):3973-9. doi: 10.4049/jimmunol.1301843.
Abstract
A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-β production and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-β regulation of T cells.
摘要
适应性免疫系统的一个基本方面是生成和维持多样化且自身耐受的 T 细胞库。通过调节 T 细胞的发育、稳态、耐受和分化，高度进化保守的细胞因子 TGF-β 对功能正常的 T 细胞池至关重要。这种调节的多效性可能归因于免疫系统中 TGF-β 产生和激活的精细控制，以及 TGF-β 信号通路的复杂性。在这篇综述中，我们讨论了目前对 TGF-β 调节 T 细胞的理解。
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