中性粒细胞与淋巴细胞比值与囊性纤维化患儿临床状态相关：一项回顾性研究。
The blood neutrophil to lymphocyte ratio correlates with clinical status in children with cystic fibrosis: a retrospective study.
机构信息
University of Arkansas for Medical Sciences College of Pharmacy, Department of Pharmacy Practice, Little Rock, Arkansas, United States of America ; University of Arkansas for Medical Sciences College of Medicine, Department of Pediatrics, Division of Pharmacology and Toxicology Little Rock, Arkansas United States.
出版信息
PLoS One. 2013 Oct 2;8(10):e77420. doi: 10.1371/journal.pone.0077420. eCollection 2013.
PURPOSE
The blood neutrophil to lymphocyte ratio (NLR) has been identified as a potentially useful marker of clinical outcome in disease states with an inflammatory component. The objective of this study was to evaluate the relationship between NLR and clinical status in children with cystic fibrosis.
METHODS
This was a retrospective chart review. Data collected included NLR, body mass index, and forced expiratory volume in 1 second (FEV1) while asymptomatic, and during hospitalizations for pulmonary exacerbation. An NLR breakpoint of 3 was used for comparisons of body mass index and FEV1.
RESULTS
A total of 159 charts were reviewed. An NLR ≥ 3 was significantly associated with lower body mass index and lower FEV1. NLR during hospitalization was significantly higher than NLR while asymptomatic. NLR measured during the first 3 months of life was negatively correlated with FEV1 at age 12.
CONCLUSION
NLR correlates with clinical status in children with cystic fibrosis and may be a useful biomarker in this population.
目的
中性粒细胞与淋巴细胞比值（NLR）已被确定为具有炎症成分的疾病状态中临床预后的一个潜在有用的标志物。本研究的目的是评估 NLR 与囊性纤维化患儿临床状况之间的关系。
方法
这是一项回顾性图表审查。收集的数据包括 NLR、体重指数和无症状时及因肺部恶化住院期间的 1 秒用力呼气量（FEV1）。使用 NLR 截断值为 3 来比较体重指数和 FEV1。
结果
共审查了 159 份图表。NLR≥3 与较低的体重指数和较低的 FEV1显著相关。住院期间的 NLR 明显高于无症状时的 NLR。生命最初 3 个月测量的 NLR 与 12 岁时的 FEV1 呈负相关。
结论
NLR 与囊性纤维化患儿的临床状况相关，可能是该人群中有用的生物标志物。
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