Butler G B, Xing Y, Gifford G E, Flick D A
Ann N Y Acad Sci. 1985;446:149-59. doi: 10.1111/j.1749-6632.1985.tb18397.x.
A series of copolymers related in structure to the 1:2 alternating cyclocopolymer of divinyl ether and maleic anhydride (DIVEMA) have been shown to possess antitumor properties. The synthesis and structures of these copolymers are discussed, and their effectiveness as antitumor agents is presented. Certain of the copolymers have been prepared in controlled molecular weight ranges using chain transfer agents, and the resultant copolymers finally fractionated via use of solvent-nonsolvent systems. These samples of narrow molecular weight distribution have been evaluated for their antitumor properties and have been found to be quite effective.
一系列在结构上与二乙烯基醚和顺丁烯二酸酐的1:2交替环共聚物（DIVEMA）相关的共聚物已被证明具有抗肿瘤特性。本文讨论了这些共聚物的合成与结构，并介绍了它们作为抗肿瘤剂的有效性。某些共聚物已使用链转移剂在可控的分子量范围内制备，最终通过使用溶剂-非溶剂体系对所得共聚物进行分级分离。对这些窄分子量分布的样品进行了抗肿瘤特性评估，发现它们相当有效。
