Ekunwe E O
Ann Trop Paediatr. 1985 Jun;5(2):103-6. doi: 10.1080/02724936.1985.11748371.
Three possible reasons for failure of measles vaccine were identified as follows: (a) circulating maternal antibodies, (b) administration of non-viable vaccine, and (c) misdiagnosis. A study designed to test the role played by each of these in the high measles vaccine failure rate was carried out at the Oguntolu Street Clinic, Lagos, from October 1982 to February 1983. Failure to seroconvert was the cause of 67.7% of measles vaccine failure, particularly at ages 6-7 months, though this was not associated with high prevaccination titres. In 32.3% incorrect diagnosis was responsible. Non-viable vaccine was found not to be a reason because all vials of measles vaccine were potent at the time of administration.
(a) 母传抗体的存在，(b) 使用了无活性疫苗，以及 (c) 误诊。1982年10月至1983年2月在拉各斯的奥贡托卢街诊所开展了一项研究，旨在检验这些因素各自在高麻疹疫苗接种失败率中所起的作用。未能产生血清转化是67.7% 的麻疹疫苗接种失败的原因，特别是在6至7个月龄时，尽管这与接种前的高滴度无关。在32.3% 的情况中，错误诊断是原因所在。发现无活性疫苗不是一个原因，因为所有麻疹疫苗小瓶在接种时都是有效的。
