Program in Nursing Science, University of California, Irvine.
Health Psychol. 2014 Sep;33(9):1046-56. doi: 10.1037/a0033968. Epub 2013 Oct 7.
Stressful life events experienced during childhood and as an adult negatively impact mental and physical health over the life span. This study examined polymorphisms from 2 hypothalamic-pituitary-adrenal axis-related genes previously associated with posttraumatic stress disorder-FKBP5 and CRHR1-as moderators of the impact of child abuse and adult stress on physical health.
A national, community-based subsample of non-Hispanic European American respondents (n = 527) from a prospective longitudinal 3-year study of stress and coping (N = 2,729) provided saliva for genotyping.
FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and adult stress to predict increases in physical health ailments over 3 years. Child abuse and adult stress were strongly related to physician-diagnosed physical ailments among individuals with the risk alleles of both single nucleotide polymorphisms. Individuals carrying the low-risk homozygotic genotypes were protected from the long-term negative health implications of experiencing both child abuse and adult stress.
Consistent with theories linking the hypothalamic-pituitary-adrenal axis with stress-related disease, hypothalamic-pituitary-adrenal axis polymorphism genotypes moderated the association between exposure to child abuse/adult stress and long-term physical health outcomes in a national sample.
儿童期和成年期经历的应激性生活事件会对整个生命周期的身心健康产生负面影响。本研究检测了先前与创伤后应激障碍相关的 2 个下丘脑-垂体-肾上腺轴相关基因 FKBP5 和 CRHR1 的多态性，作为儿童期虐待和成年期应激对身体健康影响的调节剂。
一项针对应激和应对的前瞻性纵向 3 年研究（N=2729）的全国性社区基础非西班牙裔欧洲裔美国应答者的子样本（n=527）提供唾液进行基因分型。
FKBP5(rs1360780)和 CRHR1(rs12944712)多态性与儿童虐待和成人压力显著相互作用，可预测 3 年内身体健康问题的增加。儿童虐待和成人压力与风险单核苷酸多态性个体的医生诊断的身体疾病密切相关。携带低风险纯合基因型的个体免受同时经历儿童虐待和成人压力的长期负面健康影响的保护。
与将下丘脑-垂体-肾上腺轴与应激相关疾病联系起来的理论一致，下丘脑-垂体-肾上腺轴多态性基因型调节了暴露于儿童期虐待/成年期应激与全国样本中长期身体健康结果之间的关联。
