急诊之旅：植物中的 microRNA 介导的翻译阻遏。
Trip to ER: MicroRNA-mediated translational repression in plants.
机构信息
Shenzhen Key Laboratory of Microbial Genetic Engineering; College of Life Sciences; Shenzhen University; Shenzhen, P.R. China; Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, P.R. China.
Institute of Genetics and Developmental Biology; Chinese Academy of Sciences; Beijing, P.R. China.
出版信息
RNA Biol. 2013 Oct;10(10):1586-92. doi: 10.4161/rna.26313. Epub 2013 Sep 10.
miRNAs elicit gene silencing at the post-transcriptional level by several modes of action: translational repression, mRNA decay, and mRNA cleavage. Studies in animals have suggested that translational repression occurs at early steps of translation initiation, which can be followed by deadenylation and mRNA decay. Plant miRNAs were originally thought to solely participate in mRNA cleavage, but increasing evidence has indicated that they are also commonly involved in translational inhibition. Here we discuss recent findings on miRNA-mediated translational repression in plants. The identification of AMP1 in Arabidopsis as a protein required for the translational repression but not the mRNA cleavage activity of miRNAs links miRNA-based translational repression to the endoplasmic reticulum (ER). Future work is required to further elucidate the miRNA machinery on the ER.
miRNAs 通过几种作用模式在转录后水平引发基因沉默：翻译抑制、mRNA 降解和 mRNA 切割。动物研究表明，翻译抑制发生在翻译起始的早期步骤，随后是去腺苷酸化和 mRNA 降解。植物 miRNAs 最初被认为仅参与 mRNA 切割，但越来越多的证据表明它们也通常参与翻译抑制。本文讨论了植物中 miRNA 介导的翻译抑制的最新发现。拟南芥中 AMP1 的鉴定作为一种蛋白，对于 miRNA 的翻译抑制但不是 mRNA 切割活性是必需的，将 miRNA 基的翻译抑制与内质网（ER）联系起来。需要进一步阐明 ER 上的 miRNA 机制。
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