Department of Dental Diseases, Medical Faculty, University of Ljubljana, Zaloška 2, 1000 Ljubljana, Slovenia.
Environ Toxicol Pharmacol. 2013 Nov;36(3):1040-5. doi: 10.1016/j.etap.2013.09.005. Epub 2013 Sep 19.
This study examined the bioconcentration of selected organochlorine pollutants, tetra- and hexa-chlorobiphenyls with planar (PCB-80, PCB-169) and non-planar (PCB-54, PCB-155) structure, and persistent organochlorine pesticides with planar [hexachlorobenzene (HCB)] and non-planar [1,1-bis (4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE)] structure in primary dental tissues (pulp, dentine, and enamel) and mandibular bone of lactationally exposed lambs, and compared it with the organochlorines distribution pattern in permanent dental tissues and bone. Also, the role of pollutants physicochemical properties and tissue specific characteristics in the bioconcentration was assessed. Residual levels of individual pollutants were analyzed by high-resolution gas chromatography with electron-capture detection. Our results showed that transfer of organochlorines to primary hard dental tissues was higher than to permanent hard dental tissues. Metabolically more stable, planar, and toxic organochlorines (e.g. PCB-169 and HCB) predominated in primary hard dental tissues, where they may represent a potential risk for developmental dental defects.
本研究考察了选定的有机氯污染物（具有平面（PCB-80、PCB-169）和非平面（PCB-54、PCB-155）结构的四氯和六氯联苯）和持久性有机氯农药（具有平面[六氯苯（HCB）]和非平面[1,1-双（4-氯苯基）-2,2-二氯乙烯（4,4'-DDE）]结构）在哺乳期暴露的羔羊的初级牙组织（牙髓、牙本质和牙釉质）和下颌骨中的生物浓缩情况，并将其与永久性牙组织和骨组织中的有机氯分布模式进行了比较。此外，还评估了污染物物理化学性质和组织特异性特征在生物浓缩中的作用。通过高分辨率气相色谱法和电子俘获检测分析了各污染物的残留水平。我们的结果表明，有机氯向初级硬牙组织的转移高于向永久性硬牙组织的转移。代谢更稳定、平面和有毒的有机氯（如 PCB-169 和 HCB）在初级硬牙组织中占主导地位，它们可能代表发育性牙缺陷的潜在风险。
