Department of Dental Diseases, Medical Faculty, University of Ljubljana, Hrvatski trg 6, Zaloška 2, 1000 Ljubljana, Slovenia.
Environ Toxicol Pharmacol. 2006 Jan;21(1):103-7. doi: 10.1016/j.etap.2005.08.002. Epub 2005 Oct 3.
The distribution of selected lipophilic organochlorine pollutants, including two pairs of tetra- and hexa-chlorobiphenyl isomers (PCB-54, -80, -155, -169) and organochlorine pesticides [hexachlorobenzene (HCB) and 1,1-bis(4-chlorophenyl)-2,2-dichloroethene (4,4'-DDE)], in ovine dental pulp, dentine, enamel and mandibular bone was examined. Sheeps were given a single dose of individual organochlorine (1-4μmol/kg) in olive oil by intramuscular injection and sacrificed 2 months later. Organochlorine residues were determined by gas chromatography. The highest levels of organochlorines were found in bone. The lipid adjusted levels varied significantly between tissues. Lower chlorinated, metabolically unstable, non-planar PCB-54 was enriched in enamel, while higher chlorinated, metabolically resistant, planar PCB-169 was preferentially retained in pulp. The ratio of planar to non-planar PCB homologues and pesticides (PCB-169/-155, PCB-80/-54, HCB/4,4'-DDE) decreased in the order pulp>dentine>enamel, suggesting that besides compound's lipophilicity and the tissue's lipid content, other physicochemical properties of organochlorines and tissue specific characteristics affect their distribution.
研究了绵羊牙髓、牙本质、牙釉质和下颌骨中选定的亲脂性有机氯污染物（两种四氯和六氯联苯异构体（PCB-54、-80、-155、-169）和有机氯农药[六氯苯（HCB）和 1,1-双（4-氯苯基）-2,2-二氯乙烯（4,4'-DDE）]的分布。绵羊通过肌肉注射橄榄油给予单剂量的单一有机氯（1-4μmol/kg），并在 2 个月后处死。通过气相色谱法测定有机氯残留量。有机氯在骨骼中的含量最高。调整脂类后的水平在组织之间差异显著。代谢不稳定、非平面的低氯化 PCB-54 在牙釉质中富集，而代谢稳定、平面的高氯化 PCB-169 则优先保留在牙髓中。平面与非平面 PCB 同系物和农药（PCB-169/-155、PCB-80/-54、HCB/4,4'-DDE）的比率按牙髓>牙本质>牙釉质的顺序降低，表明除了化合物的亲脂性和组织的脂质含量外，其他物理化学性质的有机氯和组织特异性特征也会影响其分布。
