绵羊脱髓鞘性脑白质炎慢病毒的核苷酸序列：与艾滋病病毒的关系。

Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus.

作者信息

Sonigo P, Alizon M, Staskus K, Klatzmann D, Cole S, Danos O, Retzel E, Tiollais P, Haase A, Wain-Hobson S

出版信息

Cell. 1985 Aug;42(1):369-82. doi: 10.1016/s0092-8674(85)80132-x.

Abstract

We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transcriptase and endonuclease/integrase domains of the visna and AIDS viruses. These findings support the inclusion of the AIDS virus in the retroviral subfamily Lentivirinae.

摘要

我们已经确定了维斯纳慢病毒完整的9202个核苷酸序列。推导得出的基因结构与艾滋病逆转录病毒的基因结构最为相似，因为存在一个将pol和env分隔开的新的中央区域。此外，维斯纳病毒和艾滋病病毒保守的逆转录酶以及核酸内切酶/整合酶结构域之间存在密切的系统发育关系。这些发现支持将艾滋病病毒归入逆转录病毒亚科慢病毒属。