Ellis John, Waldner Cheryl, Gow Sheryl, Jackson Marion
Departments of Veterinary Microbiology (Ellis), Large Animal Clinical Sciences (Waldner, Gow), and Veterinary Pathology (Jackson), Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
Can J Vet Res. 2013 Jul;77(3):205-10.
Bovine respiratory syncytial virus (BRSV) is a primary agent of pneumonia in calves that causes damage to pulmonary epithelium and results in respiratory distress. This retrospective cumulative analysis of data from 681 calves experimentally infected with BRSV was undertaken to determine if there was an association of both the partial pressure of oxygen in arterial blood (PaO₂) and the lactate concentration in arterial blood with lung lesion severity, as well as to estimate the potential predictive value of these 2 parameters in assessing disease progression. The PaO₂ was highly significantly associated with the extent of lung lesions and was considered highly predictive of lesion severity. Although the arterial blood lactate concentration was also significantly associated with lung disease, the results were not consistent for all days after challenge. Also, the lactate level was usually within the reference interval. Thus, the usefulness of the arterial blood lactate concentration in predicting the course of BRSV-associated pneumonia is limited in the clinical setting.
牛呼吸道合胞病毒（BRSV）是犊牛肺炎的主要病原体，可损害肺上皮并导致呼吸窘迫。本研究对681头经实验感染BRSV的犊牛数据进行回顾性累积分析，以确定动脉血氧分压（PaO₂）和动脉血乳酸浓度与肺损伤严重程度之间是否存在关联，并评估这两个参数在评估疾病进展中的潜在预测价值。PaO₂与肺损伤程度高度显著相关，被认为对损伤严重程度具有高度预测性。尽管动脉血乳酸浓度也与肺部疾病显著相关，但攻毒后所有天数的结果并不一致。此外，乳酸水平通常在参考区间内。因此，在临床环境中，动脉血乳酸浓度预测BRSV相关性肺炎病程的作用有限。
