铜配合物作为抗癌剂的研究进展。 - Suppr

Advances in copper complexes as anticancer agents.

作者信息

Santini Carlo, Pellei Maura, Gandin Valentina, Porchia Marina, Tisato Francesco, Marzano Cristina

机构信息

Scuola di Scienze e Tecnologie-Sez. Chimica, Università di Camerino , via S. Agostino 1, 62032 Camerino, Macerata, Italy.

出版信息

Chem Rev. 2014 Jan 8;114(1):815-62. doi: 10.1021/cr400135x. Epub 2013 Oct 8.

DOI:10.1021/cr400135x

PMID:24102434

Abstract

摘要

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Advances in copper complexes as anticancer agents.铜配合物作为抗癌剂的研究进展。

Chem Rev. 2014 Jan 8;114(1):815-62. doi: 10.1021/cr400135x. Epub 2013 Oct 8.

Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review).新型铜配合物作为癌症治疗的潜在蛋白酶体抑制剂（综述）

Mol Med Rep. 2017 Jan;15(1):3-11. doi: 10.3892/mmr.2016.6022. Epub 2016 Dec 9.

From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases.从硬币到癌症治疗：靶向人类拓扑异构酶的金、银和铜配合物。

Bioorg Med Chem Lett. 2020 Feb 1;30(3):126905. doi: 10.1016/j.bmcl.2019.126905. Epub 2019 Dec 17.

A comprehensive overview of β-carbolines and its derivatives as anticancer agents.β-咔啉及其衍生物作为抗癌剂的全面概述。

Eur J Med Chem. 2021 Nov 15;224:113688. doi: 10.1016/j.ejmech.2021.113688. Epub 2021 Jul 5.

Schiff Bases and their Metal Complexes as Potential Anticancer Candidates: A Review of Recent Works.席夫碱及其金属配合物作为潜在的抗癌候选物：近期研究进展综述。

Anticancer Agents Med Chem. 2019;19(15):1786-1795. doi: 10.2174/1871520619666190227171716.

Lasing the DNA fragments through β-diketimine framed Knoevenagel condensed Cu(II) and Zn(II) complexes--an in vitro and in vivo approach.通过β-二酮亚胺框架的 Knoevenagel 缩合 Cu(II)和 Zn(II)配合物对 DNA 片段进行激光照射——一种体外和体内方法。

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Jan 24;118:867-82. doi: 10.1016/j.saa.2013.09.109. Epub 2013 Oct 9.

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells.二乙基二硫代氨基甲酸盐与铜的复合物：在癌细胞中的作用机制。

Mini Rev Med Chem. 2012 Oct;12(12):1184-92. doi: 10.2174/138955712802762068.

Selective anticancer copper(II)-mixed ligand complexes: targeting of ROS and proteasomes.选择性抗癌铜（II）混合配体配合物：靶向活性氧和蛋白酶体。

Metallomics. 2014 Apr;6(4):892-906. doi: 10.1039/c3mt00276d.

Discovery of a potent and highly specific β proteasome inhibitor from a library of copper complexes.从铜配合物文库中发现一种强效且高度特异性的β蛋白酶体抑制剂。

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5780-5784. doi: 10.1016/j.bmcl.2016.10.043. Epub 2016 Oct 15.

Dithiocarbamate-based coordination compounds as potent proteasome inhibitors in human cancer cells.基于二硫代氨基甲酸盐的配位化合物作为人类癌细胞中有效的蛋白酶体抑制剂。

Mini Rev Med Chem. 2012 Oct;12(12):1193-201. doi: 10.2174/138955712802762040.

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Two crystal structures of copper(II) complexes and adducts based on the neutral , -dimethyl- -(pyridin-2-ylmeth-yl)ethane-1,2-di-amine ligand.基于中性的α，α-二甲基-α-（吡啶-2-基甲基）乙烷-1,2-二胺配体的铜（II）配合物和加合物的两种晶体结构。

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Preclinical Trials of Cancer Stem Cells Targeted by Metal-Based Coordination Complexes: A Systematic Review.基于金属的配位络合物靶向癌症干细胞的临床前试验：一项系统综述

Pharmaceutics. 2025 Jul 18;17(7):931. doi: 10.3390/pharmaceutics17070931.

Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects.吡啶硫酮铜，一种铜络合物，是ATG4B和自噬抑制剂，具有强大的抗癌作用。

Acta Pharmacol Sin. 2025 Jul 28. doi: 10.1038/s41401-025-01619-2.

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J Nanobiotechnology. 2025 Jul 28;23(1):544. doi: 10.1186/s12951-025-03616-3.

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Investigation of the Cytotoxicity of Cu(II), Au(III), and Pd(II) Complexes with 2,4-Dithiouracil and 6-Propyl-2-thiouracil Derivatives.含2,4-二硫代尿嘧啶和6-丙基-2-硫代尿嘧啶衍生物的铜（II）、金（III）和钯（II）配合物的细胞毒性研究

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A Multifaceted Nanodrug Disrupts the Copper-Iron Homeostasis to Enhance Cancer Radiotherapeutic Effect.一种多面纳米药物破坏铜铁稳态以增强癌症放射治疗效果。

ACS Nano. 2025 Jul 22;19(28):26091-26104. doi: 10.1021/acsnano.5c06891. Epub 2025 Jul 10.

Bilosomal Encapsulation of Binuclear Phosphino Ru(II)-Cu(II) Compounds Enhances Their Selectivity and Activity toward Lung and Prostate Cancers.双核膦基钌（II）-铜（II）化合物的脂质体包封增强了它们对肺癌和前列腺癌的选择性和活性。

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Advances in copper complexes as anticancer agents.

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