Chemistry Department, Natural Science College, Jimma University, Jimma, Ethiopia.
Anticancer Agents Med Chem. 2019;19(15):1786-1795. doi: 10.2174/1871520619666190227171716.
Schiff bases and their metal complexes are emerging as key classes of medicinal compounds, possessing an enormous potential of biological activities like anticancer, anticonvulsant and antioxidant etc. The aim of this review is to examine the anticancer activity of different classes of Schiff bases and their metal complexes.
Anticancer activity of the already synthesized as well as the novel Schiff bases and their metal complexes was studied using different assays such as 3- [4,5-dimethyltiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT), PI staining, Sulforhodamine, Allium cepa, Sulfo- Rhodamine-B-stain(SRB), viability and potato disc against various human and animal cancer cell lines.
The test results indicated significant differences in anticancer activity between subclasses of Schiff base compounds as well as between the Schiff base ligands and their metal complexes. Quinazolines showed a very high activity against HepG2 and MCF-7 cell lines. Pyrazole-naphthalene derivatives exhibited high activity against numerous carcinoma cells while [Ni(HL1)2(OAc)2] showed the highest. Azosal and its tin(IV) complexes displayed high activity against U-1242 MG and excellent activity against HCT-116 cell lines. 2-thiouracil sulfonamides displayed high activity against MCF7, CaCo-2 carcinoma cells. Vitamin-B6 and its oxovanadium complex showed good activity against MCF-7, 3T3 and cervical cancer HeLa cancer cell lines in the presence of visible light. Indoles displayed high activity against AMJ13. Porphyrines derivatives exhibited good activity while its binuclear(Y and K) complexes displayed high activity against several carcinoma cells. Chitosan complexes of [Pd(II) and Pt(II)] showed a very high anticancer activity against MCF-7 carcinoma cell.
Schiff bases possess a high potential to inhibit carcinoma cells which enhanced with complexation, but the mechanism of their antitumor activity is still doubt.
席夫碱及其金属配合物作为一类重要的药用化合物，具有巨大的生物活性潜力，如抗癌、抗惊厥和抗氧化等。本综述的目的是研究不同类型的席夫碱及其金属配合物的抗癌活性。
使用不同的测定方法，如 3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四唑溴盐（MTT）、碘化丙啶（PI）染色、磺基罗丹明、洋葱、磺基罗丹明-B 染色（SRB）、活力和马铃薯圆盘，对已合成的以及新型席夫碱及其金属配合物的抗癌活性进行研究，针对各种人类和动物癌细胞系。
试验结果表明，席夫碱化合物的亚类以及席夫碱配体及其金属配合物之间的抗癌活性存在显著差异。喹唑啉类对 HepG2 和 MCF-7 细胞系表现出非常高的活性。吡唑-萘衍生物对许多癌细胞表现出高活性，而 [Ni(HL1)2(OAc)2] 表现出最高活性。阿扎沙及其锡（IV）配合物对 U-1242 MG 表现出高活性，对 HCT-116 细胞系表现出优异的活性。2-硫代尿嘧啶磺酰胺对 MCF7、CaCo-2 癌细胞表现出高活性。维生素 B6 及其氧钒配合物在可见光下对 MCF-7、3T3 和宫颈癌 HeLa 癌细胞系表现出良好的活性。吲哚类对 AMJ13 表现出高活性。卟啉衍生物表现出良好的活性，而其双核（Y 和 K）配合物对多种癌细胞表现出高活性。[Pd(II)和 Pt(II)]的壳聚糖配合物对 MCF-7 癌细胞具有非常高的抗癌活性。
席夫碱具有抑制癌细胞的高潜力，通过配位增强，但它们的抗肿瘤活性机制仍存在疑问。
