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编码大鼠脑髓磷脂蛋白脂质的cDNA克隆的分子克隆及核苷酸序列

Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid.

作者信息

Dautigny A, Alliel P M, d'Auriol L, Pham Dinh D, Nussbaum J L, Galibert F, Jollès P

出版信息

FEBS Lett. 1985 Aug 19;188(1):33-6. doi: 10.1016/0014-5793(85)80869-3.

DOI:10.1016/0014-5793(85)80869-3
PMID:2410294
Abstract

A cDNA library from rat brain was constructed in pBR322 and screened with a 14-mer mixed oligonucleotide probe based on residues 231-235 of bovine proteolipid (PLP). A positive clone was isolated: it contained a 1334-base-pair cDNA insert and was subjected to DNA sequence analysis. The cDNA encoded information for the 276 amino acids of rat PLP. Comparison with bovine PLP sequence showed a complete amino acid sequence homology except for 4 amino acid residues.

摘要

用pBR322构建大鼠脑cDNA文库，并用基于牛蛋白脂质（PLP）第231 - 235位残基的14聚体混合寡核苷酸探针进行筛选。分离出一个阳性克隆：它含有一个1334碱基对的cDNA插入片段，并进行了DNA序列分析。该cDNA编码大鼠PLP的276个氨基酸的信息。与牛PLP序列比较显示，除了4个氨基酸残基外，氨基酸序列完全同源。

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