KK Women's and Children's Hospital, Singapore, Singapore.
BMC Pediatr. 2013 Oct 8;13:161. doi: 10.1186/1471-2431-13-161.
Continuous surveillance for intussusception (IS) is important for monitoring the safety of second-generation rotavirus vaccines. The present study aimed to assess the incidence of IS in Singaporean children aged < 2 years.
This was a prospective, hospital-based, multi-center surveillance conducted in seven hospitals - two public hospitals and five private medical centers between May 2002 and June 2010 in Singapore. Diagnosis of IS (definite, probable, possible, suspected) was based on the case definition developed by the Brighton Collaboration. Children < 2 years of age who were diagnosed with IS were enrolled in this study. Incidence of IS was calculated per 100,000 child-year with its 95% confidence interval.
Of the 178 children enrolled, 167 children with definite IS cases were considered for final analyses; 11 were excluded (six diagnosed as probable IS and four diagnosed as suspected IS; one child's parents withdrew consent). Mean age of children with definite IS was 11.6 ± 6 months; 67.7% were males. The overall incidence of IS was 28.9 (95% CI: 23.0-34.8) and 26.1 (95% CI: 22.2-30.0) per 100,000 child-year in children < 1 year and < 2 years of age, respectively. The majority of IS cases (20 [12.0%]) were reported in children aged 6 months. Most children (98.2% [164/167]) recovered, two (1.2%) children recovered with sequelae and one (0.6%) child died of septic shock.
The incidence of IS remained low and stable in Singaporean children aged < 2 years during the study period (May 2002 to June 2010).
NCT01177839.
连续监测肠套叠（IS）对于监测第二代轮状病毒疫苗的安全性非常重要。本研究旨在评估新加坡 2 岁以下儿童 IS 的发病率。
这是一项在新加坡七家医院（两家公立医院和五家私立医疗中心）进行的前瞻性、基于医院的多中心监测。IS（明确、可能、疑似）的诊断基于布莱顿合作组织制定的病例定义。诊断为 IS 的年龄<2 岁的儿童被纳入本研究。IS 的发病率按每 10 万名儿童年计算，置信区间为 95%。
在纳入的 178 名儿童中，有 167 名患有明确 IS 病例的儿童被纳入最终分析；11 名儿童被排除在外（6 名被诊断为可能 IS，4 名被诊断为疑似 IS；一名儿童的父母撤回了同意）。患有明确 IS 的儿童的平均年龄为 11.6±6 个月；67.7%为男性。IS 的总发病率为 28.9（95%CI：23.0-34.8）和 26.1（95%CI：22.2-30.0）/10 万名儿童年，分别在<1 岁和<2 岁的儿童中。大多数 IS 病例（20[12.0%]）发生在 6 个月大的儿童中。大多数儿童（98.2%[164/167]）康复，2 名（1.2%）儿童康复后有后遗症，1 名（0.6%）儿童死于感染性休克。
在研究期间（2002 年 5 月至 2010 年 6 月），新加坡<2 岁儿童的 IS 发病率仍然较低且稳定。
NCT01177839。
