Life science and technology, Xinjiang University, Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Urumqi 830046, China.
BMC Genet. 2013 Oct 9;14:100. doi: 10.1186/1471-2156-14-100.
Uyghurs are one of the many populations of Central Eurasia that is considered to be genetically related to Eastern and Western Eurasian populations. However, there are some different opinions on the relative importance of the degree of Eastern and Western Eurasian genetic influence. In addition, the genetic diversity of the Uyghur in different geographic locations has not been clearly studied.
In this study, we are the first to report on the DNA polymorphism of cytochrome B in the Uyghur population located in Xinjiang in northwest China. We observed a total of 102 mutant sites in the 240 samples that were studied. The average number of mutated nucleotides in the samples was 5.126. A total of 93 different haplotypes were observed. The gene diversity and discrimination power were 0.9480 and 0.9440, respectively. There were founder and bottleneck haplotypes observed in Xinjiang Uyghurs. Xinjiang Uyghurs are more genetically related to Chinese population in genetics than to Caucasians. Moreover, there was genetic diversity between Uyghurs from the southern and northern regions. There was significance in genetic distance between the southern Xinjiang Uyghurs and Chinese population, but not between the northern Xinjiang Uyghurs and Chinese. The European vs. East Asian contribution to the ten regional Uyghur groups varies among the groups and the European contribution to the Uyghur increases from north to south geographically.
This study is the first report on DNA polymorphisms of cytochrome B in the Uyghur population. The study also further confirms that there are significant genetic differences among the Uyghurs in different geographical locations.
维吾尔族是中亚众多族群之一，被认为与东亚和欧洲人群在基因上有关。然而，对于东西方欧亚遗传影响的相对重要性，存在一些不同的观点。此外，不同地理位置的维吾尔族的遗传多样性尚未得到明确研究。
本研究首次报道了位于中国西北部新疆的维吾尔族人群细胞色素 B 的 DNA 多态性。我们共观察到 240 个样本中的 102 个突变位点。样本中突变核苷酸的平均数量为 5.126。共观察到 93 种不同的单倍型。基因多样性和鉴别力分别为 0.9480 和 0.9440。在新疆维吾尔族中存在创始者和瓶颈单倍型。从遗传学角度看，新疆维吾尔族与中国人群的遗传关系比与高加索人群更密切。此外，南北疆维吾尔族之间存在遗传多样性。南疆维吾尔族与中国人群的遗传距离具有统计学意义，但北疆维吾尔族与中国人群之间无统计学意义。十个地区维吾尔族群体中欧洲和东亚对其的贡献因群体而异，而且维吾尔族的欧洲贡献从北到南呈地理分布递增。
本研究首次报道了维吾尔族人群细胞色素 B 的 DNA 多态性。该研究还进一步证实，不同地理位置的维吾尔族之间存在显著的遗传差异。
