针对微生物抗原的天然存在的唾液抗体的免疫球蛋白A亚类分布
Immunoglobulin A subclass distribution of naturally occurring salivary antibodies to microbial antigens.
作者信息
Brown T A, Mestecky J
出版信息
Infect Immun. 1985 Aug;49(2):459-62. doi: 10.1128/iai.49.2.459-462.1985.
Abstract
The distribution of immunoglobulin A1 (IgA1) and IgA2 antibodies to various microbial antigens was determined in human parotid saliva by using monoclonal antibodies to the IgA subclasses in a solid-phase radioimmunoassay. In 12 subjects examined, antibodies to Streptococcus mutans glucosyl transferase, protein antigen I/II, and cell wall carbohydrate, as well as dextrans B1355 fraction S and B512 and phosphorylcholine, occurred predominantly in the IgA1 subclass. In contrast, antibodies to lipoteichoic acid from Streptococcus pyogenes and whole lipopolysaccharides from Bacteroides gingivalis, Bacteroides fragilis, and Escherichia coli were predominantly of the IgA2 subclass. The data indicate that in most individuals naturally occurring antibodies to a given antigen are predominantly associated with one of the two subclasses of IgA.
摘要
采用针对免疫球蛋白A（IgA）亚类的单克隆抗体，通过固相放射免疫测定法，测定了人腮腺唾液中针对各种微生物抗原的免疫球蛋白A1（IgA1）和IgA2抗体的分布。在接受检查的12名受试者中，针对变形链球菌葡糖基转移酶、蛋白抗原I/II和细胞壁碳水化合物的抗体，以及右旋糖酐B1355组分S和B512以及磷酰胆碱的抗体，主要存在于IgA1亚类中。相比之下，针对化脓性链球菌脂磷壁酸以及牙龈拟杆菌、脆弱拟杆菌和大肠杆菌全脂多糖的抗体主要属于IgA2亚类。数据表明，在大多数个体中，针对特定抗原的天然抗体主要与IgA的两个亚类之一相关。
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