Zielinski C C, Preis P, Aiginger P, Eibl M M
J Cancer Res Clin Oncol. 1985;110(1):65-70. doi: 10.1007/BF00402504.
Serum concentrations of acute-phase-proteins C-reactive protein (CRP), alpha 1-antitrypsin (AAT), alpha 1-acid glycoprotein (AGP) as well as levels of immunoglobulins G, A and M and of complement components C3 and C4 were evaluated in 15 patients with advanced (stages III and IV) Hodgkin's disease. Of these patients 9 suffered from B symptoms including pruritus, night sweats and fever. While all patients had highly increased concentrations of CRP and AAT and 11 patients also had elevated levels of AGP in their sera, these concentrations were significantly (P less than 0.001) reducible by the administration of chemotherapy. Patients with B symptoms also had significantly higher concentrations of CRP (P less than 0.02), AAT (P less than 0.05) and AGP (P less than 0.05) in their sera than patients without. Plasmapheresis which was performed in 3 patients did not achieve a long-lasting reduction of serum concentrations of any acute-phase-protein tested. Complement components C3 and C4 exhibited a similar behaviour as acute-phase-proteins in that they were elevated in patients with B symptoms and reducible by the administration of chemotherapy (P less than 0.001 and P less than 0.02, respectively). We conclude that serum concentrations of CRP, AAT and AGP can serve as useful markers for the assessment of tumour activity in patients with advanced Hodgkin's disease. Whereas the concentrations of immunoglobulins G and A in patients were comparable to normal controls, IgM was significantly (P less than 0.05) reduced in patients who had received chemotherapy, but not in those who were newly diagnosed and had not received any treatment. Thus, chemotherapy lowered serum concentrations of IgM without influencing levels of IgG and IgA.
对15例晚期（III期和IV期）霍奇金病患者的血清急性期蛋白C反应蛋白（CRP）、α1抗胰蛋白酶（AAT）、α1酸性糖蛋白（AGP）以及免疫球蛋白G、A、M水平和补体成分C3、C4进行了评估。这些患者中有9例出现B症状，包括瘙痒、盗汗和发热。所有患者血清中CRP和AAT浓度均显著升高，11例患者血清中AGP水平也升高，而化疗可使这些浓度显著降低（P<0.001）。有B症状的患者血清中CRP（P<0.02）、AAT（P<0.05）和AGP（P<0.05）浓度也显著高于无B症状的患者。对3例患者进行的血浆置换未实现对所检测的任何急性期蛋白血清浓度的持久降低。补体成分C3和C4的表现与急性期蛋白相似，即在有B症状的患者中升高，化疗可使其降低（分别为P<0.001和P<0.02）。我们得出结论，CRP、AAT和AGP的血清浓度可作为评估晚期霍奇金病患者肿瘤活性的有用标志物。患者的免疫球蛋白G和A浓度与正常对照组相当，而接受化疗的患者IgM显著降低（P<0.05），但新诊断且未接受任何治疗的患者IgM未降低。因此，化疗降低了血清IgM浓度，而不影响IgG和IgA水平。
