Mignot E, Serrano A, Laude D, Elghozi J L, Dedek J, Scatton B
J Neural Transm. 1985;62(1-2):117-24. doi: 10.1007/BF01260421.
The relationship between the concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in the CSF and in the striatum has been evaluated in the rat by measuring the levels of this metabolite in ventricular CSF (by liquid chromatography coupled with electrochemical detection) and in the striatal extracellular fluid (by in vivo voltammetry) after administration of inhibitors of serotonin synthesis or degradation. Pargyline, NSD 1015 and alpha-propyldopacetamide all caused an exponential decline of 5-HIAA in both CSF and striatum. For a given drug, the rate constants for 5-HIAA disappearance were identical in the CSF and in the striatal extracellular fluid. These results confirm the view that CSF 5-HIAA may serve as a good index of brain serotonin turnover.
通过测量给予血清素合成或降解抑制剂后大鼠脑室脑脊液（采用液相色谱-电化学检测法）和纹状体细胞外液（采用体内伏安法）中该代谢物的水平，评估了脑脊液和纹状体中5-羟吲哚乙酸（5-HIAA）浓度之间的关系。帕吉林、NSD 1015和α-丙基多巴胺酰胺均导致脑脊液和纹状体中5-HIAA呈指数下降。对于给定药物，脑脊液和纹状体细胞外液中5-HIAA消失的速率常数相同。这些结果证实了脑脊液5-HIAA可作为脑血清素周转率良好指标的观点。
