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己酮可可碱可预防急性给予 3,4-亚甲二氧基甲基苯丙胺（MDMA 或摇头丸）导致的大鼠肝纤维化和细胞凋亡。

Pentoxifylline Protects the Rat Liver Against Fibrosis and Apoptosis Induced by Acute Administration of 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy).

机构信息

Department of Anatomy, Islamic Azad University Tehran Medical Branch, Tehran, Iran.

出版信息

Iran J Basic Med Sci. 2013 Aug;16(8):922-7.

PMID:24106597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3786105/
Abstract

OBJECTIVE(S): 3,4-Methylenedioxymethamphetamine (MDMA) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in liver cells. The present study aimed to investigate the effects of pentoxifylline (PTX) on liver damage induced by acute administration of MDMA in Wistar rat.

MATERIALS AND METHODS

Animals were administered with saline or MDMA (7.5 mg/kg, IP) 3 times with 2 hr intervals. PTX (200 mg kg, IP), was administered simultaneously with last injection of MDMA in experimental group.

RESULTS

The concomitant administration of pentoxifylline and MDMA decreased liver injury including apoptosis, fibrosis and hepatocytes damages.

CONCLUSION

Our results showed for the first time that PTX treatment diminishes the extent of apoptosis and fibrosis caused by MDMA in rat liver.

摘要

目的

3,4-亚甲二氧基甲基苯丙胺（MDMA）是世界上最受欢迎的滥用药物之一，具有致幻特性，已被证明可诱导肝细胞凋亡。本研究旨在探讨己酮可可碱（PTX）对 Wistar 大鼠急性 MDMA 给药引起的肝损伤的影响。

材料和方法

动物给予生理盐水或 MDMA（7.5mg/kg，IP），3 次，间隔 2 小时。PTX（200mgkg，IP）在实验组最后一次 MDMA 注射时同时给药。

结果

同时给予己酮可可碱和 MDMA 可减少肝损伤，包括凋亡、纤维化和肝细胞损伤。

结论

我们的结果首次表明，PTX 治疗可减轻 MDMA 引起的大鼠肝损伤中的细胞凋亡和纤维化程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/909a442480f9/ijbms-16-922-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/19f3f876aa7c/ijbms-16-922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/44c4c413af29/ijbms-16-922-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/f1932ab057f1/ijbms-16-922-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/909a442480f9/ijbms-16-922-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/19f3f876aa7c/ijbms-16-922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/44c4c413af29/ijbms-16-922-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/f1932ab057f1/ijbms-16-922-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c07f/3786105/909a442480f9/ijbms-16-922-g004.jpg

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