Cihák A, Korbová L
Neoplasma. 1985;32(3):293-8.
Of different N-alkyl substituted derivatives of 5-azacytidine tested for their action on gastric secretion in rats with ligated pylorus the most effective beside 5-azacytidine were N4-methyl and N4,N4-dimethyl derivatives. The drugs blocked gastric secretion, gastric acidity, the extent of hemorrhage and the number and size of gastric defects. Simultaneously a higher synthesis of RNA in the liver of drug-treated animals was observed.
在对5-氮杂胞苷的不同N-烷基取代衍生物进行测试，以研究其对幽门结扎大鼠胃分泌的作用时，除5-氮杂胞苷外，最有效的是N4-甲基和N4,N4-二甲基衍生物。这些药物可阻断胃分泌、胃酸度、出血程度以及胃损伤的数量和大小。同时，在接受药物治疗的动物肝脏中观察到RNA合成增加。
