Cihák A, Korková L, Kohout J, Reutter W
Neoplasma. 1978;25(3):317-27.
Out of different azapyrimidines tested for their ability to affect metabolism of orotic acid in the liver of rats kept on food only 5-azacytidine resulted in the enhanced incorporation of orotate into liver RNA following 24 hr pretreatment. Similar effect was observed also in cycloheximide-treated animals. No stimulation of orotic acid utilization following 5-azacytidine or cycloheximidine treatment was observed in the liver of starved animals. Both drugs (but not other pyrimidine analogues tested) depressed markedly gastric secretion in rats and caused decreased evacuation of the stomach. The decreased secretion of pepsin and lower gastric acidity resulting in drug-simulated starvation of the treated animals are discussed in relation to the enhanced uptake of orotic acid into liver RNA.
在仅喂食食物的大鼠肝脏中，对不同氮杂嘧啶进行测试，以考察其影响乳清酸代谢的能力。仅5-氮杂胞苷在预处理24小时后，导致乳清酸盐掺入肝脏RNA的量增加。在环己酰亚胺处理的动物中也观察到类似的效果。在饥饿动物的肝脏中，未观察到5-氮杂胞苷或环己酰亚胺处理后对乳清酸利用的刺激作用。这两种药物（但不是所测试的其他嘧啶类似物）显著抑制大鼠的胃液分泌，并导致胃排空减少。结合乳清酸摄入肝脏RNA增加的情况，讨论了胃蛋白酶分泌减少和胃酸降低导致经药物处理动物出现类似饥饿状态的问题。
