Chakarova P, Budevsky O
Pharmazie. 1975 Aug;30(8):524-7.
Because of weak acid-base properties, many pharmaceuticals cannot be determined by the convenient neutralization titrimetric method. It is shown that such substances can be precisely analyzed by applying the graphic pH-potentiometric method of Gran. Some water-soluble and insoluble pharmaceuticals, which usually are analyzed in nonaqueous solvents, have been determined precisely in water solution by this method. The latter is also applied successfully to the analysis of mixtures and impurities in pharmaceuticals.
由于许多药物具有弱酸碱性，无法用便捷的中和滴定法进行测定。研究表明，应用格兰氏图解pH电位滴定法可对这类物质进行精确分析。一些通常在非水溶剂中分析的水溶性和水不溶性药物，已通过该方法在水溶液中得到精确测定。该方法还成功应用于药物混合物及杂质的分析。
